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WormBase Tree Display for Variation: WBVar00143592

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Name Class

WBVar00143592NamePublic_namee912
Other_nameF59G1.4a.1:c.250-263_947-68del
HGVSgCHROMOSOME_II:g.5896964_5902373del
Sequence_detailsSMapS_parentSequenceF59G1
Flanking_sequencesaggaaggaacaagtcgatcggaaaattttattttcacactgggagctagttccaataaaa
Mapping_targetF59G1
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004403
WBStrain00006311
WBStrain00026764
WBStrain00026863
WBStrain00027055
WBStrain00027229
WBStrain00027586
WBStrain00040213
WBStrain00040275
WBStrain00051497
LaboratoryCB
StatusLive
AffectsGeneWBGene00002993
WBGene00198855
WBGene00199631
WBGene00197123
WBGene00019128
TranscriptF59G1.6
F59G1.13VEP_consequencetranscript_ablation
VEP_impactHIGH
Exon_number1/1
F59G1.10VEP_consequencetranscript_ablation
VEP_impactHIGH
Exon_number1/1
F59G1.4a.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScF59G1.4a.1:c.250-263_947-68del
Intron_number4-10/14
Exon_number5-10/15
F59G1.12VEP_consequencetranscript_ablation
VEP_impactHIGH
Exon_number1/1
Interactor (17)
IsolationMutagen
GeneticsInterpolated_map_positionII-0.855656
Mapping_dataIn_2_point40
777
4220
In_multi_point (11)
In_pos_neg_data3708
4223
4224
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
PenetranceHighSevere Egl phenotype is also observed at 15 CPaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Range9999Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0000022Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000033Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkHeterochronic defectPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0000065Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayGenotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0000070Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayGenotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0000113Paper_evidenceWBPaper00056201
Curator_confirmedWBPerson44293
RemarkFigure 2a, e912 mutants have elevated SL1-LCE expression at later larval stagesPaper_evidenceWBPaper00056201
Curator_confirmedWBPerson44293
WBPhenotype:0000114Paper_evidenceWBPaper00026761
Curator_confirmedWBPerson712
RemarkCompared to the greater than 5-fold decrease in lin-14 and in lin-28 mRNA levels in wild-type worms, the levels of these mRNAs remained nearly constant from the L1- to the L2-stage in lin-4(e912) worms.Paper_evidenceWBPaper00026761
Curator_confirmedWBPerson712
WBPhenotype:0000137Paper_evidenceWBPaper00031252
Curator_confirmedWBPerson712
RemarkIn mixed stage lin-4(lf) animals, the enrichment of lin-14 in the AIN-2 IP result is significantly decreased compared to that in the WT background. In contrast, the enrichment of two other known miRNA targets, hbl-1 and lin-28, was similarPaper_evidenceWBPaper00031252
Curator_confirmedWBPerson712
WBPhenotype:0000154Person_evidenceWBPerson13152
Curator_confirmedWBPerson712
WBPhenotype:0000164Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0000201Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
RemarkAdult animals do not express adult-specific surface antigens.Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005755PATO:0000460Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAdult animals (n=300) were incubated with 6ul total anti-adult antiserum cross-adsorbed with N2 L4's and 14ul 125I-protein A.Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
WBPhenotype:0000428Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkLacks adult cuticle.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000432Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAdult males lack copulatory structures.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000438Paper_evidenceWBPaper00001144
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkHeterochronic, retarded adult hermaphrodites. Easy to score (ES3) in adult, very hard to score (ES1) in larvae.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Animals continue past the L4 molt to an L5 stage animal, not to an adult stage.Paper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000643Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkabnormal movementPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000698Paper_evidenceWBPaper00000762
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
PenetranceCompleteAt 15 C, 4 percent of e912 hermaphrodites have recognizable vulval structuresPaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Range100100Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive20Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0001228Paper_evidenceWBPaper00001144
Person_evidenceWBPerson13152
Curator_confirmedWBPerson712
RemarkAnimals do not form adult lateral alae.Paper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00001144
Curator_confirmedWBPerson712
WBPhenotype:0001414Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Remarkmale mating is completely abolishedPaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
PenetranceHighPaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayGenotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0001687Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
RemarkAdult animals do not express adult-specific surface antigens.Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005755PATO:0000460Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAdult animals (n=300) were incubated with 6ul total anti-adult antiserum cross-adsorbed with N2 L4's and 14ul 125I-protein A.Paper_evidenceWBPaper00001002
Curator_confirmedWBPerson712
WBPhenotype:0001923Person_evidenceWBPerson13152
Curator_confirmedWBPerson712
WBPhenotype:0002154Paper_evidenceWBPaper00032489
Curator_confirmedWBPerson712
RemarkExtracts from late L2 stage wild-type and lin-4(e912) mutant animals showed that experimentally validated target mRNAs, lin-14 and lin-28, were shifted into the polysomal fraction in the mutant. By contrast, polysome association of the control mRNAs act-1 and ama-1 and the let-7 target daf-12 is identical in lin-4(e912) and wild-type animals.Paper_evidenceWBPaper00032489
Curator_confirmedWBPerson712
WBPhenotype:0002157Paper_evidenceWBPaper00032489
Curator_confirmedWBPerson712
Remarklin-14 and lin-28 transcript levels are increased in lin-4 mutants compared with wild-type animals, whereas daf-12, act-1 and ama-1 mRNA levels remain unchanged.Paper_evidenceWBPaper00032489
Curator_confirmedWBPerson712
WBPhenotype:0004001Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkHermaphrodite mating never successful (HME0) at 20C, rarely successful (HME1) at 15C.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive20Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000207Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkDefecation cycle is normalPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0000634Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkPumping is normalPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0000637Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkNo defects in dauer formationPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0001233Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
RemarkCell number and nuclear staining is normalPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentDAPI stainingPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBPhenotype:0002535Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Remarknon-DyfPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005666PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0005667PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0005668PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0005665PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0005661PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0007807PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
WBbt:0007808PATO:0000460Paper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentDiO stainingPaper_evidenceWBPaper00031335
Curator_confirmedWBPerson2021
ReferenceWBPaper00031335
WBPaper00015101
WBPaper00017778
WBPaper00032489
WBPaper00014165
WBPaper00015201
WBPaper00016053
WBPaper00020777
WBPaper00014384
WBPaper00020928
WBPaper00026761
WBPaper00031252
WBPaper00000762
WBPaper00016473
WBPaper00013667
WBPaper00014071
WBPaper00016093
WBPaper00015978
WBPaper00010918
WBPaper00014199
WBPaper00014557
WBPaper00015615
WBPaper00016094
WBPaper00014480
WBPaper00014638
WBPaper00013917
WBPaper00014335
WBPaper00020760
WBPaper00020855
WBPaper00013918
WBPaper00001002
WBPaper00019534
WBPaper00001144
WBPaper00056201
WBPaper00062103
MethodDeletion_allele