WormBase Tree Display for RNAi: WBRNAi00107682

WBRNAi00107682 Homol: Homol_homol: ZK112:RNAi
  Sequence_info: PCR_product: sjj_ZK112.7
  Experiment: Delivered_by: Bacterial_feeding
  Inhibits: Predicted_gene: ZK112.7 Inferred_automatically: RNAi_primary
    Gene: WBGene00000395 Inferred_automatically: RNAi_primary
    Transcript: ZK112.7.1 Inferred_automatically: RNAi_primary
  Species: Caenorhabditis elegans
  Reference: WBPaper00045833
  Phenotype: WBPhenotype:0000529 Remark: "During AC invasion, the c-fos transcription factor ortholog fos-1 promotes expression the zinc metalloprotease zmp-1, the protocadherin cdh-3, the zinc finger protein egl-43, the hemicentin extracellular matrix protein gene him-4, and lamillopodin/mig-10; the activities of these genes induce the AC to form ventrally directed protrusions that breach the basement membrane (Fig 6A; Sherwood et_al, 2005; Hwang et_al 2007; Wang et_al, 2014). RNAi against the AC invasion genes resulted in defects in utse development (Table 2E; Fig 6B-D; F-H; J-L; N-P; R-T; V-X), supporting our hypothesis that genes involved in AC protrusion formation also affect utse development."
      Penetrance: Incomplete
        Range: 39
      EQ_annotations: Anatomy_term: WBbt:0006789 PATO:0000460
  Remark: (Table 2, Figure 6) cdh-3 RNAi
  Method: RNAi