WormBase Tree Display for Picture: WBPicture0000007170

WBPicture0000007170 Description: This gene has homology to the family of G-protein coupled receptors. Expression first becomes evident at the first larval stage, L1, when the head body-wall muscles and an unidentified cell(s) in the anal region harbour stain. The anal staining lasts only until L2/3, whilst the head muscles continue showing expression right through to adulthood. The expression pattern includes a further component in the vm1 cells associated with the vulva. These specialised muscle cells attach to the ventral hypodermis and the vulval labia, and are important in opening the vulva during egg-laying. Expression here is transient, seen only for a short time around the L4 to adult molt. All components of the expression pattern are non-nuclear localised. As the expression vector includes an effective nuclear localisation signal (NLS), this observation suggests that sequences present in the fusion protein are overriding the NLS and causing localisation of the fusion protein to another cellular compartment. As ZK643.3 is similar to a family of G-protein coupled receptors, this compartment may be assumed to be the plasma lemma, though this cannot be confirmed by the light microscope observations performed thus far.
  Name: zk643_3f.jpg
  Remark: Lynch AS et al. (1995) Nat Genet. Developmental expression pattern screen for genes predicted in the C. elegans ...
  Depict: Expr_pattern: Expr17
  Acknowledgment: Person_name: Ian Hope
  Contact: WBPerson266