WormBase Tree Display for Interaction: WBInteraction000558195
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WBInteraction000558195 | Interaction_type | Regulatory | Change_of_expression_level |
---|---|---|---|
Interactor | Interactor_overlapping_gene (2) | ||
Interaction_summary | "A lacZ-lin-41 fusion transgene expresses LacZ in the seam cells under the translational control of let-7 (ref. 19). In wild-type animals, LacZ staining in the seam cells can be observed from the L1 stage through to L4. The staining is absent in adult animals as a consequence of let-7-mediated repression (Fig. 4a, b). As expected, suppression of alg-1 and dcr-1 by RNAi resulted in persistence of LacZ staining in adults[20-22] (Fig. 4c, d). Next, we used RNAi to analyse the involvement of VIG-1 and TSN-1 in let-7 function. RNAi against either VIG-1 or TSN-1 results in persistent expression of the LacZ reporter in the seam cells of adult animals (Fig. 4e, f)." | ||
Detection_method | Reporter_gene | [lacZ::lin-41] | |
Regulation_result | Negative_regulate (2) | ||
Paper | WBPaper00006077 | ||
Remark | Fig. 4 |