WormBase Tree Display for Interaction: WBInteraction000542333
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| WBInteraction000542333 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00004303 | Interactor_type | Trans_regulator | |
| WBGene00003210 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr4321 | ||||
| Interaction_summary | ran-2 (RanGAP) severely disrupted MEL-28 localization in the early embryo and prevented MEL-28 localization to both chromatin and nuclear membranes. | ||||
| Detection_method | In_situ | ||||
| Regulation_result | Positive_regulate | Subcellular_localization | chromatin and the nuclear envelope | ||
| Interaction_RNAi | WBRNAi00065354 | ||||
| Paper | WBPaper00028457 | ||||
| Antibody_remark | WBPaper00028457]:mel-28 | ||||
| Remark | Although chromatin maintenance and nuclear-envelope function can be genetically separated, MEL-28 and the Ran cycle are required for both. These observations are consistent with the idea that MEL-28 plays roles in nuclear-envelope integrity and chromatin maintenance and does so in a Ran-dependent manner. |
