WormBase Tree Display for Interaction: WBInteraction000542152
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| WBInteraction000542152 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00000298 | Interactor_type | Trans_regulated | |
| Molecule_interactor | WBMol:00001980 | Interactor_type | Trans_regulator | ||
| Interaction_summary | "Chronic exposure to nicotine at the micromolar range induced aberrant gene expressions in wt C. elegans across all dosed concentrations. Fig. 4 shows the fold change in gene expression of the 18 tested genes, varying from 12.5-fold down-regulation (old-1) to 138.1-fold up-regulation (hlh-14). Statistical analysis indicate that there were 10 tested genes expressed aberrantly in response to at least one dosage of nicotine. These 10 genes are egl-10, egl-44, hlh-14, ric-3, unc-103, unc-50, unc-68, sod-1, oxi-1, and old-1. Among the 10 genes, 8 genes (egl-10, egl-44, hlh-14, ric-3, unc-103, unc-50, unc-68, and oxi-1) were significantly up-regulated, 2 genes (sod-1 and old-1) were significantly down-regulated. Gene regulation is the most active at two low nicotine treatment groups; 3 (egl-44, ric-3, and old-1) and 7 tested genes (egl-10, hlh-14, unc-103, unc-50, unc-68, sod-1, and oxi-1) were differentially expressed at 1 ppm and 3.16 ppm treatment groups, respectively. In contrast, only 3 (egl-44, ric-3, and old-1) and 1 tested genes (ric-3) were significantly changed at 10 ppm and 31.6 ppm treatment groups, respectively. Changes in gene expressions were the most significant under 3.16 ppm nicotine exposure; six genes (egl-10, hlh-14, unc-103, unc-50, unc-68, and oxi-1) displayed at least 10-fold significant up-regulation." | ||||
| Detection_method | RT_PCR | ||||
| Regulation_level | Transcriptional | ||||
| Paper | WBPaper00042470 | ||||
| Remark | Fig. 4 |
