WormBase Tree Display for Interaction: WBInteraction000541124

WBInteraction000541124 Interaction_type: Regulatory: Change_of_localization
  Interactor: Interactor_overlapping_gene: WBGene00000187 Interactor_type: Trans_regulated
        Expr_pattern: Expr11058
        Transgene: WBTransgene00008450
        Construct: WBCnstr00008156
      WBGene00003100 Interactor_type: Trans_regulator
      WBGene00012832 Interactor_type: Trans_regulator
    Variation_interactor: WBVar00143854 Interactor_type: Trans_regulator
      WBVar00092556 Interactor_type: Trans_regulator
  Interaction_summary: "We also wanted to determine how genes involved in executing morphogenesis might be affected by DMD-3 and MAB-3... At early L4, ARL- 1::GFP is expressed intensely in the hyp10 cell in most mab- 3(e1240);dmd-3(ok1327) mutant males (21/34 males), whereas this reporter was expressed intensely in only few wild-type males (4/32; Figure 7B). On the other hand, mutant adults lack the PHCL/R expression (absent in 40/41 males) that is present in all wild-type males (N=35) (Figure 7B). Thus, arl-1 expression is controlled by dmd-3 and/or mab-3, positively in the neurons but negatively in hyp10."
  Detection_method: Construct
    Reporter_gene: [arl-1::gfp]
    Transgene
  Regulation_level: Post_translational
  Regulation_result: Negative_regulate: Life_stage: WBls:0000073
      Anatomy_term: WBbt:0004378
  Paper: WBPaper00038232
  Remark: Fig. 7b