WormBase Tree Display for Interaction: WBInteraction000535532
expand all nodes | collapse all nodes | view schema
| WBInteraction000535532 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001130 | Interactor_type | Trans_regulated | |
| Transgene | WBTransgene00022959 | ||||
| WBGene00001580 | Interactor_type | Trans_regulator | |||
| Interaction_summary | "As described previously, DYN-1-GFP foci localize across the cortex before the onset of polarity establishment in wild-type embryos. The foci become enriched in the anterior and are maintained through cytokinesis (Figure 2C, control; Nakayama et_al, 2009)... To determine whether the disruption in DYN-1-GFP foci to the cortex was specific to Arp2/3-regulated actin dynamics, we again disrupted WAVE function through gex-3 RNAi and quantified the number of DYN-1 foci at the cortex (Figure 2, C and D). We found that disruption of WAVE/SCAR function by gex-3 RNAi also significantly reduces the number of DYN-1-GFP cortical foci, similar to arx-2 RNAi, suggesting that localization of DYN-1 cortex relies on Arp2/3 and WAVE/SCAR-mediated actin dynamics." | ||||
| Detection_method | Reporter_gene | DYN-1::GFP | |||
| Transgene | |||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000003 | ||
| Subcellular_localization | cortex | ||||
| Interaction_RNAi | WBRNAi00107864 | ||||
| Paper | WBPaper00040933 |
