WormBase Tree Display for Interaction: WBInteraction000525192
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| WBInteraction000525192 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003172 | Interactor_type | Trans_regulator | |
| WBGene00022816 | Interactor_type | Trans_regulated | |||
| Variation_interactor | WBVar00266651 | Interactor_type | Trans_regulator | ||
| Interaction_summary | Based on the tiling array, the region of fun-1 that is misrelated in mech-8 mutants spans eons 14-19, which includes the region of fbn-1 that is alternatively spliced (exon 14-16). Most notably, expression of an fun-1 cDNA driven by native fbn-1 promoter sequences partially rescued the synthetic lethality of mec-8;sum-4 mutants in two independent lines. This latter finding indicates that fun-1 is a critical target for misregulation in mec-8;sum-4 mutants. | ||||
| Detection_method | Other_method | tiling array | |||
| Regulation_level | Post_transcriptional | ||||
| Paper | WBPaper00046588 |
