WormBase Tree Display for Interaction: WBInteraction000524109
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| WBInteraction000524109 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001170 | Interactor_type | Cis_regulated | |
| Feature_interactor | WBsf919552 | Interactor_type | Cis_regulator | ||
| Interaction_summary | Sequence inspection revealed that Region B contains four closely spaced Snail- binding sites, DNA-binding sites for members of the Snail family of zinc-finger transcription factors (Hemavathy et al., 2000). The core motif of three of these binding sites is completely conserved in C. briggsae (binding sites I, II and IV; 6/6 bases identical), and one of them has one base change in C. briggsae (binding site III; 5/6 bases identical). The sequence of binding sites I and II of C. elegans is a perfect match to the sequence of the core motif of a consensus Snail-binding site (5'-CACCTG-3') whereas the sequences of binding sites III and IV have one mismatch to the consensus sequence (5'- CATCTG-3' and 5'-CAGCTG-3', respectively). Binding of CES-1 to Region B was severely reduced after the introduction of point mutations that destroy the core motif of the four Snail-binding sites. | ||||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Negative_regulate | Anatomy_term | WBbt:0006245 | ||
| Paper | WBPaper00006120 |
