WormBase Tree Display for Interaction: WBInteraction000520771
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WBInteraction000520771 | Interaction_type | Regulatory | Change_of_localization | ||
---|---|---|---|---|---|
Interactor | Interactor_overlapping_gene | WBGene00003992 | Interactor_type | Trans_regulated | |
Expr_pattern | Expr2999 | ||||
Transgene | WBTransgene00000160 | ||||
Construct | WBCnstr00000160 | ||||
Antibody | WBAntibody00000021 | ||||
WBGene00013766 | Interactor_type | Trans_regulator | |||
Variation_interactor | WBVar02125122 | Interactor_type | Trans_regulator | ||
Interaction_summary | During C. elegans embryogenesis, P granule components PGL-1 and PGL-3 in somatic cells are selectively degraded by autophagy, resulting in their exclusive localization in germline cell lineages. We performed genetic screens and isolated a recessive mutation, named epg-11(bp292), that caused the accumulation of GFP::PGL-1 granules in somatic cells during embryogenesis. Immunostaining with specific antibodies showed that endogenous PGL-1 and PGL-3 also accumulated into a large number of aggregates that completely colocalized in somatic cells in epg-11 mutant embryos. | ||||
Detection_method | Construct | ||||
Antibody | |||||
Reporter_gene | [pgl-1::gfp] | ||||
Transgene | |||||
Regulation_level | Post_transcriptional | ||||
Regulation_result | Negative_regulate | Life_stage | WBls:0000003 | ||
Anatomy_term | WBbt:0008378 | ||||
Paper | WBPaper00044350 |