WormBase Tree Display for Interaction: WBInteraction000504444
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| WBInteraction000504444 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003003 | Interactor_type | Trans_regulator | |
| WBGene00003014 | Interactor_type | Trans_regulated | |||
| Variation_interactor | WBVar00089301 | Interactor_type | Trans_regulator | ||
| Interaction_summary | To test whether it is also a positive regulator of lin-28 in the HSNs, GFP expression was quantified in lin-14(lf); lin-28::GFP animals that were maintained at the restrictive 23uC temperature (Figure 4C, 4F, and 4G). Introduction of the lin-14 mutant allele resulted in a significant decrease in GFP expression in the HSNs at the L2 and L3 stages, leading to complete down-regulation of the reporter one stage earlier than in wild-type animals grown under the same conditions | ||||
| Detection_method | Reporter_gene | [lin-28::gfp] | |||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000027 | ||
| WBls:0000035 | |||||
| Anatomy_term | WBbt:0006830 | ||||
| Paper | WBPaper00036764 |
