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WormBase Tree Display for Gene: WBGene00003003

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Name Class

WBGene00003003SMapS_parentSequenceT25C12
IdentityVersion1
NameCGC_namelin-14Person_evidenceWBPerson261
Sequence_nameT25C12.1
Molecular_nameT25C12.1a
T25C12.1a.1
CE43285
T25C12.1b
CE03734
T25C12.1b.1
Other_nameCELE_T25C12.1Accession_evidenceNDBBX284606
Public_namelin-14
DB_infoDatabaseAceViewgeneXM103
WormQTLgeneWBGene00003003
WormFluxgeneWBGene00003003
NDBlocus_tagCELE_T25C12.1
NCBIgene181337
RefSeqproteinNM_077515.5
NM_077516.7
SwissProtUniProtAccQ21446
TREEFAMTREEFAM_IDTF316913
UniProt_GCRPUniProtAccQ21446
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlin
Reference_alleleWBVar00089301
WBVar00089587
Allele (337)
Legacy_informationClass 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage.
See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842
[C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT]
Strain (20)
RNASeq_FPKM (74)
GO_annotation (16)
Ortholog (28)
Structured_descriptionConcise_descriptionlin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR.Paper_evidenceWBPaper00000620
WBPaper00001137
WBPaper00001468
WBPaper00001829
WBPaper00001848
WBPaper00003931
WBPaper00005159
Curator_confirmedWBPerson1843
Date_last_updated02 Sep 2005 00:00:00
Automated_descriptionEnables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Molecular_infoCorresponding_CDST25C12.1a
T25C12.1b
Corresponding_CDS_historyT25C12.1a:wp196
Corresponding_transcriptT25C12.1a.1
T25C12.1b.1
Other_sequence (11)
Associated_feature (55)
Transcription_factorWBTranscriptionFactor000395
Experimental_infoRNAi_result (17)
Expr_pattern (13)
Drives_constructWBCnstr00000926
WBCnstr00007336
WBCnstr00007627
WBCnstr00015030
WBCnstr00015050
WBCnstr00015780
WBCnstr00015781
WBCnstr00036292
Construct_productWBCnstr00000967
WBCnstr00007627
WBCnstr00019563
WBCnstr00019564
WBCnstr00021119
WBCnstr00021910
WBCnstr00036292
Regulate_expr_clusterWBPaper00026952:class_A
WBPaper00026952:class_B
WBPaper00026952:class_C
WBPaper00026952:class_D
WBPaper00026952:class_E
WBPaper00026952:class_F
WBPaper00026952:class_G
WBPaper00026952:class_H
AntibodyWBAntibody00000046
WBAntibody00000337
WBAntibody00000338
WBAntibody00001031
WBAntibody00001569
WBAntibody00001873
Microarray_results (33)
Expression_cluster (170)
Interaction (256)
WBProcessWBbiopr:00000031
WBbiopr:00000057
WBbiopr:00000083
Map_infoMapXPosition3.78431Error0.060767
Well_ordered
PositiveInside_rearrnDf19
yDp8
yDp10
Positive_clonePPE4
T25C12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point251
492
636
637
688
3648
3652
Multi_point (22)
Pos_neg_data3918
3920
654
668
3155
294
1831
8427
Reference (365)
MethodGene