WormBase Tree Display for Interaction: WBInteraction000502604
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WBInteraction000502604 | Interaction_type | Regulatory | Change_of_localization | ||
---|---|---|---|---|---|
Interactor | Interactor_overlapping_gene | WBGene00004303 | Interactor_type | Trans_regulator | |
WBGene00003210 | Interactor_type | Trans_regulated | |||
Expr_pattern | Expr4321 | ||||
Interaction_summary | ran-2 (RanGAP) severely disrupted MEL-28 localization in the early embryo and prevented MEL-28 localization to both chromatin and nuclear membranes. | ||||
Detection_method | In_situ | ||||
Regulation_result | Positive_regulate | Life_stage | WBls:0000003 | ||
Interaction_RNAi | WBRNAi00065354 | ||||
Paper | WBPaper00028457 | ||||
Antibody_remark | WBPaper00028457]:mel-28 | ||||
Remark | Although chromatin maintenance and nuclear-envelope function can be genetically separated, MEL-28 and the Ran cycle are required for both. These observations are consistent with the idea that MEL-28 plays roles in nuclear-envelope integrity and chromatin maintenance and does so in a Ran-dependent manner. |