WormBase Tree Display for Gene: WBGene00022675
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| WBGene00022675 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | gbb-2 | Person_evidence | WBPerson6553 | |||||
| Sequence_name | ZK180.1 | ||||||||
| Molecular_name | ZK180.1 | ||||||||
| ZK180.1.1 | |||||||||
| CE43384 | |||||||||
| Other_name | CELE_ZK180.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | gbb-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:06 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 04 Jun 2008 11:48:40 | WBPerson2970 | Name_change | CGC_name | gbb-2 | ||||
| 3 | 06 Nov 2008 15:22:36 | WBPerson1849 | Event | Acquires_merge | WBGene00022676 | ||||
| Acquires_merge | WBGene00022676 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gbb | ||||||||
| Allele (231) | |||||||||
| Strain | WBStrain00055690 | ||||||||
| WBStrain00055694 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00021528 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | gbb-2 encodes a subunit of the GABAB receptor dimer (GBB-1/2) that is required for inhibition of cholinergic motor neurons by GABA, and thus for normally restrained movement and aldicarb resistance; gbb-2(tm1165) mutants move abnormally fast, with abnormally few changes of direction; GBB-2 is orthologous to human GABBR2 (OMIM:607340, associated with susceptibility to nicotine dependence). | Paper_evidence | WBPaper00031872 | |||||
| WBPaper00032008 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Dec 2009 00:00:00 | ||||||||
| Automated_description | Enables G protein-coupled GABA receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 59 and nicotine dependence. Is an ortholog of human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080291 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4507) | ||||
| DOID:0050742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4507) | ||||||
| DOID:1574 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4507) | ||||||
| Molecular_info | Corresponding_CDS | ZK180.1 | |||||||
| Corresponding_CDS_history | ZK180.1:wp124 | ||||||||
| ZK180.1:wp197 | |||||||||
| Corresponding_transcript | ZK180.1.1 | ||||||||
| Other_sequence (35) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00077396 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00021904 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050794 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059263 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021905 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059262 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1017442 | ||||||||
| Expr1040020 | |||||||||
| Expr1162690 | |||||||||
| Expr2011956 | |||||||||
| Expr2030193 | |||||||||
| Microarray_results (38) | |||||||||
| Expression_cluster (188) | |||||||||
| Map_info | Map | IV | Position | 0.413979 | Error | 0.013668 | |||
| Positive | Positive_clone | ZK180 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
