WormBase Tree Display for Gene: WBGene00022500
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WBGene00022500 | Evidence | Paper_evidence | WBPaper00013452 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | ZC8 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lfi | ||||||
Allele (252) | |||||||
Strain | WBStrain00032313 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00023076 | ||||||
00023077 | |||||||
Ortholog (43) | |||||||
Paralog | WBGene00018051 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | lfi-1 encodes, by alternative splicing, at least four isoforms of alarge coiled-coil protein paralogous to F35D11.11, and possiblyorthologous to rootletin (the structural protein comprising ciliaryrootlets); LFI-1 is also homologous to the Parascaris univalens MitoticAntigen, PUMA1; LFI-1 was initially identified in yeast two-hybrid screens for proteins that interact with the coiled-coil protein LIN-5, which is essential for proper spindle positioning and chromosome segregation; antibody staining reveals that, in embryos, LFI-1 is expressed in metaphase cells in a diffuse area surrounding the kinetochore microtubules and overlapping with LIN-5 localization; in interphase cells, LFI-1 localizes to the nucleus and remains in the nuclear region even after nuclear envelope breakdown; as loss of lfi-1 activity, or the combined activities of lfi-1 and a related gene, F35D11.11, by RNAi results in no obvious defects, the precise role of LFI-1 in development is not yet known. | Paper_evidence | WBPaper00024244 | |||
WBPaper00029004 | |||||||
WBPaper00029016 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 07 Feb 2007 00:00:00 | ||||||
Automated_description | Located in kinetochore microtubule and nucleus. Is an ortholog of human CROCC (ciliary rootlet coiled-coil, rootletin). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | EFO:0009151 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1859) | ||
Molecular_info | Corresponding_CDS | ZC8.4a | |||||
ZC8.4d | |||||||
ZC8.4e | |||||||
ZC8.4f | |||||||
ZC8.4g | |||||||
ZC8.4h | |||||||
Corresponding_CDS_history (5) | |||||||
Corresponding_transcript | ZC8.4a.1 | ||||||
ZC8.4a.2 | |||||||
ZC8.4a.3 | |||||||
ZC8.4a.4 | |||||||
ZC8.4d.1 | |||||||
ZC8.4e.1 | |||||||
ZC8.4f.1 | |||||||
ZC8.4g.1 | |||||||
ZC8.4h.1 | |||||||
Other_sequence (219) | |||||||
Associated_feature (9) | |||||||
Transcription_factor | WBTranscriptionFactor000405 | ||||||
Experimental_info | RNAi_result | WBRNAi00021759 | Inferred_automatically | RNAi_primary | |||
WBRNAi00002294 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062893 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038104 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059021 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00017162 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00070889 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00034411 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062898 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00070888 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr2936 | ||||||
Expr1013576 | |||||||
Expr1039943 | |||||||
Expr1162452 | |||||||
Expr2013090 | |||||||
Expr2031322 | |||||||
Drives_construct | WBCnstr00024200 | ||||||
Construct_product | WBCnstr00024200 | ||||||
WBCnstr00038856 | |||||||
Antibody | WBAntibody00000895 | ||||||
WBAntibody00001192 | |||||||
Microarray_results (48) | |||||||
Expression_cluster (263) | |||||||
Interaction (51) | |||||||
Map_info | Map | X | Position | -6.19862 | Error | 0.000328 | |
Positive | Positive_clone | ZC8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00010599 | ||||||
WBPaper00018632 | |||||||
WBPaper00023417 | |||||||
WBPaper00024244 | |||||||
WBPaper00038491 | |||||||
WBPaper00055090 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |