WormBase Tree Display for Gene: WBGene00022069
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| WBGene00022069 | SMap | S_parent | Sequence | Y67D8C | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | eel-1 | Person_evidence | WBPerson470 | |||||
| WBPerson498 | |||||||||
| Sequence_name | Y67D8C.5 | ||||||||
| Molecular_name (24) | |||||||||
| Other_name | CELE_Y67D8C.5 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | eel-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 04 May 2007 15:12:14 | WBPerson2970 | Name_change | CGC_name | eel-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | eel | ||||||||
| Allele (305) | |||||||||
| Possibly_affected_by | WBVar02154079 | ||||||||
| Strain | WBStrain00036324 | ||||||||
| WBStrain00022503 | |||||||||
| WBStrain00048931 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00007009 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009738 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022358 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003898 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008429 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009460 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016405 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017782 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021685 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | eel-1 encodes a predicted Hect E3 ubiquitin ligase that contains multiple domains of similarity to the mammalian Mcl1 ubiquitin ligase Mule; eel-1 (enhancer of efl-1) was identified in a screen for modifiers of the transcription factor efl-1/E2F which is involved in the generation of SKN-1 protein asymmetry in the early embryo, a process essential for proper embryonic patterning; EEL-1 binds SKN-1 in yeast two-hybrid assays; genetic interaction studies indicate that eel-1 acts redundantly with one or more EFL-1 targets to regulate the spatial and temporal expression of SKN-1, most likely by promoting SKN-1 degradation; eel-1 is also involved in the organization of hemidesmosomes by maintaining proper levels of one of the constituent proteins, LET-805/myotactin (the putative hemidesmosome extracellular matrix receptor). | Paper_evidence | WBPaper00030734 | |||||
| WBPaper00035946 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 10 Jan 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; hemidesmosome assembly; and signal transduction in response to DNA damage. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including hermaphrodite gonad; intestine; neurons; pharynx; and vulva. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Is an ortholog of human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060309 | Homo sapiens | Paper_evidence | WBPaper00051148 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Nov 2017 00:00:00 | ||||||||
| Potential_model | DOID:0060811 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30892) | |||||
| Models_disease_asserted | WBDOannot00000448 | ||||||||
| WBDOannot00000449 | |||||||||
| Molecular_info | Corresponding_CDS | Y67D8C.5a | |||||||
| Y67D8C.5b | |||||||||
| Y67D8C.5c | |||||||||
| Y67D8C.5d | |||||||||
| Y67D8C.5e | |||||||||
| Y67D8C.5f | |||||||||
| Y67D8C.5g | |||||||||
| Y67D8C.5h | |||||||||
| Corresponding_CDS_history | Y67D8C.5:wp82 | ||||||||
| Corresponding_transcript | Y67D8C.5a.1 | ||||||||
| Y67D8C.5b.1 | |||||||||
| Y67D8C.5c.1 | |||||||||
| Y67D8C.5d.1 | |||||||||
| Y67D8C.5e.1 | |||||||||
| Y67D8C.5f.1 | |||||||||
| Y67D8C.5g.1 | |||||||||
| Y67D8C.5h.1 | |||||||||
| Other_sequence (133) | |||||||||
| Associated_feature | WBsf667808 | ||||||||
| WBsf981708 | |||||||||
| WBsf995848 | |||||||||
| WBsf995849 | |||||||||
| WBsf995850 | |||||||||
| WBsf1017002 | |||||||||
| WBsf1017003 | |||||||||
| WBsf1017004 | |||||||||
| WBsf229861 | |||||||||
| WBsf229862 | |||||||||
| Experimental_info | RNAi_result (33) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00011450 | ||||||||
| WBCnstr00022909 | |||||||||
| WBCnstr00039216 | |||||||||
| WBCnstr00042403 | |||||||||
| Construct_product | WBCnstr00011490 | ||||||||
| WBCnstr00042403 | |||||||||
| Microarray_results (35) | |||||||||
| Expression_cluster (164) | |||||||||
| Interaction (58) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| Map_info | Map | IV | Position | -6.25739 | Error | 0.097532 | |||
| Positive | Positive_clone | Y67D8C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
