WormBase Tree Display for Gene: WBGene00021905
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| WBGene00021905 | SMap | S_parent | Sequence | Y55B1AL | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | helq-1 | Paper_evidence | WBPaper00035885 | |||||
| Person_evidence | WBPerson1839 | ||||||||
| Sequence_name | Y55B1AL.3 | ||||||||
| Molecular_name | Y55B1AL.3a | ||||||||
| Y55B1AL.3a.1 | |||||||||
| CE27019 | |||||||||
| Y55B1AL.3b | |||||||||
| CE37439 | |||||||||
| Y55B1AL.3b.1 | |||||||||
| Y55B1AL.3b.2 | |||||||||
| Y55B1AL.3b.3 | |||||||||
| Other_name | hel-308 | Paper_evidence | WBPaper00031868 | ||||||
| Person_evidence | WBPerson1839 | ||||||||
| Y55B1AL.a | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y55B1AM.c | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y55B1AL.3 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | helq-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 23 May 2008 16:32:58 | WBPerson2970 | Name_change | CGC_name | hel-308 | ||||
| 3 | 17 Feb 2012 16:36:47 | WBPerson2970 | Name_change | CGC_name | helq-1 | ||||
| Other_name | hel-308 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | helq | ||||||||
| Allele (197) | |||||||||
| Strain | WBStrain00051049 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP3828 | ||||||||
| Ortholog (44) | |||||||||
| Paralog (42) | |||||||||
| Structured_description | Concise_description | hel-308 encodes a putative DNA helicase orthologous to human HELQ and Drosophila MUS301/SPN-C/CG7972-PA; Drosophila MUS301 is required for normal resistance to nitrogen mustard (HN2) and to the crosslinking agent cisplatin, and is probably also required for repair of meiotic double-stranded DNA breaks; human HELQ is a single-strandedDNA-dependent ATPase and DNA helicase, and archaeal Hel308 (Mth810) may act at stalled replication forks by displacing lagging strands; HEL-308, HELQ, and CG7972-PA are paralogous to the N-terminal DNA helicase domains of human DNA POLYMERASE THETA (POLQ, OMIM:604419), Drosophila MUS308, and a putative C. elegans POLQ ortholog, encoded by polq-1; HEL-308, HELQ, and CG7972-PA belong to the superfamily II of DNA and RNA helicases; HEL-308 is probably, like MUS301, required for recombinational repair of cross-linkage or double-stranded breaks in DNA; biochemically, HEL-308 may unwind regions of cross-linked DNA before their repair by other proteins (such as POLQ), or resolve Holliday junctions after homologous recombination (as is done by the archaeal homolog Hjm). | Paper_evidence | WBPaper00027733 | |||||
| WBPaper00027734 | |||||||||
| WBPaper00027735 | |||||||||
| WBPaper00028278 | |||||||||
| WBPaper00028286 | |||||||||
| WBPaper00028287 | |||||||||
| WBPaper00028309 | |||||||||
| WBPaper00028314 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 18 Jan 2010 00:00:00 | ||||||||
| Automated_description | Enables ATPase binding activity and single-stranded DNA helicase activity. Involved in DNA metabolic process. Predicted to be located in chromosome and nucleus. Is an ortholog of human HELQ (helicase, POLQ like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y55B1AL.3a | |||||||
| Y55B1AL.3b | |||||||||
| Corresponding_CDS_history | Y55B1AL.3:wp130 | ||||||||
| Corresponding_transcript | Y55B1AL.3a.1 | ||||||||
| Y55B1AL.3b.1 | |||||||||
| Y55B1AL.3b.2 | |||||||||
| Y55B1AL.3b.3 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf666524 | ||||||||
| WBsf666525 | |||||||||
| WBsf226109 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr1017320 | ||||||||
| Expr1039622 | |||||||||
| Expr1160933 | |||||||||
| Expr2012396 | |||||||||
| Expr2030632 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (62) | |||||||||
| Interaction | WBInteraction000032681 | ||||||||
| WBInteraction000033808 | |||||||||
| WBInteraction000035421 | |||||||||
| WBInteraction000330840 | |||||||||
| WBInteraction000368494 | |||||||||
| WBInteraction000410172 | |||||||||
| WBInteraction000522568 | |||||||||
| WBInteraction000522569 | |||||||||
| WBInteraction000522570 | |||||||||
| Map_info | Map | III | Position | -26.7032 | Error | 0.05609 | |||
| Positive | Positive_clone | Y55B1AL | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031868 | ||||||||
| WBPaper00032410 | |||||||||
| WBPaper00035885 | |||||||||
| WBPaper00036289 | |||||||||
| WBPaper00037751 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00051338 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00061346 | |||||||||
| WBPaper00062246 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
