WormBase Tree Display for Gene: WBGene00021697
expand all nodes | collapse all nodes | view schema
WBGene00021697 | SMap | S_parent | Sequence | Y48G9A | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||||
Name | CGC_name | gcn-1 | Person_evidence | WBPerson644 | |||||
Sequence_name | Y48G9A.3 | ||||||||
Molecular_name (3) | |||||||||
Other_name | Y48G9A.a | Curator_confirmed | WBPerson1983 | ||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
Y48G9A.l | Curator_confirmed | WBPerson1983 | |||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
Y48G9A.m | Curator_confirmed | WBPerson1983 | |||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
Y48G9A.n | Curator_confirmed | WBPerson1983 | |||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
Y48G9A.o | Curator_confirmed | WBPerson1983 | |||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
CELE_Y48G9A.3 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | gcn-1 | ||||||||
DB_info | Database | AceView | gene | 3D249 | |||||
WormQTL | gene | WBGene00021697 | |||||||
WormFlux | gene | WBGene00021697 | |||||||
NDB | locus_tag | CELE_Y48G9A.3 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00021697|UniProtKB=B3CJ34 | |||||||
family | PTHR23346 | ||||||||
NCBI | gene | 190051 | |||||||
RefSeq | protein | NM_001381763.1 | |||||||
TREEFAM | TREEFAM_ID | TF105398 | |||||||
TrEMBL | UniProtAcc | B3CJ34 | |||||||
UniProt_GCRP | UniProtAcc | B3CJ34 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:31:04 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 15 Sep 2008 11:24:05 | WBPerson2970 | Name_change | CGC_name | gcn-1 | ||||
3 | 07 May 2008 11:46:03 | WBPerson1867 | Event | Acquires_merge | WBGene00021695 | ||||
Acquires_merge | WBGene00021695 | ||||||||
WBGene00021696 | |||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | gcn | ||||||||
Allele (932) | |||||||||
Strain | WBStrain00034488 | ||||||||
WBStrain00027623 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (13) | |||||||||
Contained_in_operon | CEOP3834 | ||||||||
Ortholog (53) | |||||||||
Paralog | WBGene00008422 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00010364 | Caenorhabditis elegans | From_analysis | Panther | ||||||
Structured_description | Concise_description | gcn-1 encodes the C. elegans ortholog of the S. cerevisiae ribosome-associated protein Gcn1p; GCN-1, along with ABCF-3, is required for maintaining the steady-state levels of phosphorylated eIF2alpha, and thus for the translational control of a number of mRNAs; GCN-1 activity is required, in parallel to, or downstream of, the canonical apoptotic pathway, for apoptotic cell death of most somatic cells and germ cells in response to ionizing radiation; in addition, GCN-1 is required for normal growth rates, and spatial organization of germ cells in the gonad; as in S. cerevisiae, GCN-1 physically interacts with ABCF-3, the C. elegans ortholog of budding yeast Gcn20p, and GCN-1 and ABCF-3 are each required for the other's stability; a gcn-1::gfp promoter fusion is expressed in most cells, including germ cells, throughout development. | Paper_evidence | WBPaper00045601 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 15 Aug 2014 00:00:00 | ||||||||
Automated_description | Predicted to enable protein kinase regulator activity. Involved in positive regulation of peptidyl-serine phosphorylation; regulation of apoptotic process; and regulation of translation. Acts upstream of with a positive effect on positive regulation of gene expression. Acts upstream of or within with a negative effect on negative regulation of translation. Predicted to be located in cytosolic ribosome. Expressed in several structures, including body wall musculature; head neurons; hermaphrodite gonad; intestinal cell; and pharyngeal neurons. Is an ortholog of human GCN1 (GCN1 activator of EIF2AK4). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | Y48G9A.3 | |||||||
Corresponding_CDS_history | Y48G9A.3:wp150 | ||||||||
Y48G9A.3:wp191 | |||||||||
Y48G9A.3:wp237 | |||||||||
Y48G9A.3:wp275 | |||||||||
Corresponding_transcript | Y48G9A.3.1 | ||||||||
Other_sequence (91) | |||||||||
Associated_feature (40) | |||||||||
Experimental_info | RNAi_result | WBRNAi00056982 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00056977 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00037280 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00093045 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077044 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00037275 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00056981 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr11922 | ||||||||
Expr11923 | |||||||||
Expr1022586 | |||||||||
Expr1039504 | |||||||||
Expr1160428 | |||||||||
Expr2011967 | |||||||||
Expr2030204 | |||||||||
Drives_construct | WBCnstr00019541 | ||||||||
Construct_product | WBCnstr00019540 | ||||||||
Regulate_expr_cluster | WBPaper00065578:gcn-1(nc40)_downregulated | ||||||||
WBPaper00065578:gcn-1(nc40)_upregulated | |||||||||
Antibody | WBAntibody00002554 | ||||||||
Microarray_results (42) | |||||||||
Expression_cluster (163) | |||||||||
Interaction (150) | |||||||||
Map_info | Map | III | Position | -15.0586 | Error | 0.039572 | |||
Positive | Positive_clone | Y48G9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (11) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |