WormBase Tree Display for Gene: WBGene00020712

WBGene00020712 SMap: S_parent: Sequence: T23B3
  Identity: Version: 2
    Name: CGC_name: ckr-1
      Sequence_name: T23B3.4
      Molecular_name: T23B3.4
        T23B3.4.1
        CE45656
      Other_name: CELE_T23B3.4 Accession_evidence: NDB BX284601
      Public_name: ckr-1
    DB_info: Database: AceView gene 1H260
        WormQTL gene WBGene00020712
        WormFlux gene WBGene00020712
        NDB locus_tag CELE_T23B3.4
        Panther gene CAEEL|WormBase=WBGene00020712|UniProtKB=P91487
          family PTHR24238
        NCBI gene 188774
        RefSeq protein NM_059517.4
        TREEFAM TREEFAM_ID TF316712
        TrEMBL UniProtAcc P91487
        UniProt_GCRP UniProtAcc P91487
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 15 Nov 2007 11:28:24 WBPerson2970 Name_change: CGC_name: ckr-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ckr
    Allele (46)
    Strain: WBStrain00032608
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (29)
    Paralog: WBGene00005745 Caenorhabditis elegans From_analysis: Panther
      WBGene00007908 Caenorhabditis elegans From_analysis: Panther
      WBGene00008737 Caenorhabditis elegans From_analysis: Panther
      WBGene00011265 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00016761 Caenorhabditis elegans From_analysis: Panther
      WBGene00016842 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00022004 Caenorhabditis elegans From_analysis: Panther
      WBGene00021439 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: T23B3.4 encodes a seven transmembrane receptor that is most closely related to the mammalian cholecystokinin receptors; loss of T23B3.4 activity via RNAi, either singly or in combination with another cholecystokinin receptor-encoding gene, Y39A3B.5, has no effect on fat metabolism, however large-scale RNAi screens have reported that T23B3.4(RNAi) results in embryonic lethality and reduced brood sizes; a T23B3.4::GFP reporter is expressed in a subset of nerve ring neurons. Paper_evidence: WBPaper00024497
            WBPaper00031090
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Oct 2007 00:00:00
      Automated_description: Predicted to enable neuropeptide receptor activity. Involved in determination of adult lifespan. Predicted to be located in plasma membrane. Expressed in intestine; nerve ring; and neurons. Human ortholog(s) of this gene implicated in cholelithiasis; obesity; and pancreatic ductal carcinoma. Is an ortholog of human CCKAR (cholecystokinin A receptor). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3587 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1570)
      DOID:10211 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1570)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1570)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1570)
  Molecular_info: Corresponding_CDS: T23B3.4
    Corresponding_CDS_history: T23B3.4:wp221
    Corresponding_transcript: T23B3.4.1
    Other_sequence (12)
    Associated_feature: WBsf983981
      WBsf219618
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr4995
      Expr16009
      Expr16053
      Expr1023812
      Expr1157440
      Expr2010034
      Expr2028275
    Drives_construct: WBCnstr00012398
      WBCnstr00024941
      WBCnstr00042664
      WBCnstr00042740
    Construct_product: WBCnstr00024941
      WBCnstr00042664
    Microarray_results (18)
    Expression_cluster (101)
    Interaction (21)
  Map_info: Map: I Position: 1.28924 Error: 0.002293
    Positive: Positive_clone: T23B3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene