WormBase Tree Display for Gene: WBGene00020316

WBGene00020316 SMap: S_parent: Sequence: T07E3
  Identity: Version: 2
    Name: CGC_name: brc-2 Person_evidence: WBPerson1551
      Sequence_name: T07E3.5
      Molecular_name: T07E3.5
        T07E3.5.1
        CE32718
      Other_name: 3H990 Accession_evidence: EMBL AY523518
        CELE_T07E3.5 Accession_evidence: NDB BX284603
      Public_name: brc-2
    DB_info: Database: AceView gene 3H990
        WormQTL gene WBGene00020316
        WormFlux gene WBGene00020316
        NDB locus_tag CELE_T07E3.5
        NCBI gene 175962
        RefSeq protein NM_066101.8
        SwissProt UniProtAcc G5EG86
        TREEFAM TREEFAM_ID TF343088
        UniProt_GCRP UniProtAcc G5EG86
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 04 Nov 2004 16:11:20 WBPerson2970 Name_change: CGC_name: brc-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: brc
    Allele (43)
    Strain: WBStrain00036382
      WBStrain00006441
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (24)
    Structured_description: Concise_description: brc-2 encodes a BRC domain-containing protein that is homologous to human BRCA2 which when mutated leads to early-onset breast cancer 2 or hereditary male breast cancer (OMIM:600185); in C. elegans, BRC-2 activity is essential for RAD-51-mediated repair of meiotic and radiation-induced double-strand breaks (DSBs); BRC-2 physically interacts with RAD-51 and single-stranded DNA and is required for proper localization of RAD-51 to sites of DNA damage and stabilization of RAD-51-DNA filaments; BRC-2 can also promote RAD-51-independent DSB repair via single-strand annealing (SSA) when the homologous recombination (HR) and nonhomologous end joining pathways (NHEJ) are compromised; in nonirradiated animals, BRC-2 is seen at diffuse, low levels in germline nuclei, but upon radiation treatment BRC-2 localizes to discrete foci that coincide with presumptive sites of DNA damage. Paper_evidence: WBPaper00025138
            WBPaper00026962
            WBPaper00027753
            WBPaper00029356
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 08 May 2007 00:00:00
      Automated_description: Enables single-stranded DNA binding activity. Involved in several processes, including DNA metabolic process; egg-laying behavior; and embryo development. Located in condensed nuclear chromosome. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T07E3.5
    Corresponding_CDS_history: T07E3.5:wp88
    Corresponding_transcript: T07E3.5.1
    Other_sequence: CJC14464_1
    Associated_feature: WBsf667022
      WBsf226879
  Experimental_info: RNAi_result: WBRNAi00052766 Inferred_automatically: RNAi_primary
      WBRNAi00005928 Inferred_automatically: RNAi_primary
      WBRNAi00052765 Inferred_automatically: RNAi_primary
      WBRNAi00008015 Inferred_automatically: RNAi_primary
      WBRNAi00018374 Inferred_automatically: RNAi_primary
      WBRNAi00035309 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3478
      Expr1017015
      Expr1038851
      Expr1156374
      Expr2009649
      Expr2027888
    Drives_construct: WBCnstr00000420
      WBCnstr00025227
    Construct_product: WBCnstr00000420
      WBCnstr00025227
    Antibody: WBAntibody00000837
      WBAntibody00000838
    Microarray_results (19)
    Expression_cluster (102)
    Interaction (38)
  Map_info: Map: III Position: -0.907107 Error: 0.001414
    Positive: Positive_clone: T07E3 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4172
    Pseudo_map_position
  Reference (27)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene