WormBase Tree Display for Gene: WBGene00020267
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| WBGene00020267 | SMap | S_parent | Sequence | T05H4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | Sequence_name | T05H4.4 | |||||||
| Molecular_name | T05H4.4 | ||||||||
| T05H4.4.1 | |||||||||
| CE13275 | |||||||||
| Other_name | CELE_T05H4.4 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | T05H4.4 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Allele (24) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00028239 | ||||||||
| 00028240 | |||||||||
| 00028241 | |||||||||
| 00028242 | |||||||||
| 00028243 | |||||||||
| 00028244 | |||||||||
| 00124938 | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00020268 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00013123 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | The T05H4.4 gene encodes a homolog of the human gene CYB5R3, which encodes a cytochrome b5 reductase. | Paper_evidence | WBPaper00004637 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 05 Jun 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable FAD binding activity. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in estrogen-receptor negative breast cancer and methemoglobinemia. Is an ortholog of human CYB5R1 (cytochrome b5 reductase 1) and CYB5R3 (cytochrome b5 reductase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060076 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2873) | ||||
| DOID:10783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2873) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2873) | ||||||
| Disease_relevance | The human genes CYB5R1, CYB5R2, and CYB5R3 (orthologous to elegans T05H4.4) encode cytochrome b5 reductases; CYB5R3 catalyses the transfer of reducing equivalents from NADH to cytochrome b5; CYB5R3 plays a role in cholesterol biosynthesis and fatty acid elongation and desaturation, while the soluble form of CYB5R3 in erythrocytes reduces methemoglobin to hemoglobin; mutations in CYB5R3 are associated with Methemoglobinemia, a blood disorder characterized by increased levels of an atypical form of hemoglobin that is unable to deliver oxygen efficiently. | Homo sapiens | Accession_evidence | OMIM | 250800 | ||||
| 613213 | |||||||||
| 608342 | |||||||||
| 608341 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T05H4.4 | |||||||
| Corresponding_transcript | T05H4.4.1 | ||||||||
| Other_sequence (16) | |||||||||
| Associated_feature | WBsf231880 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00035242 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00026206 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00071535 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026205 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027459 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090944 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00052591 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018263 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076655 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1020879 | ||||||||
| Expr1038823 | |||||||||
| Expr1156205 | |||||||||
| Expr2005909 | |||||||||
| Expr2024125 | |||||||||
| Drives_construct | WBCnstr00025252 | ||||||||
| Construct_product | WBCnstr00025252 | ||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (79) | |||||||||
| Interaction (14) | |||||||||
| Map_info | Positive | Positive_clone | T05H4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Interpolated_map_position | V | -0.16672 | |||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00049152 | |||||||||
| WBPaper00055090 | |||||||||
| Method | Gene |
