WormBase Tree Display for Gene: WBGene00019771
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WBGene00019771 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | Sequence_name | M04F3.5 | |||||||
Molecular_name | M04F3.5a | ||||||||
M04F3.5a.1 | |||||||||
CE51704 | |||||||||
M04F3.5b | |||||||||
CE31974 | |||||||||
M04F3.5b.1 | |||||||||
Other_name | CELE_M04F3.5 | Accession_evidence | NDB | BX284601 | |||||
Public_name | M04F3.5 | ||||||||
DB_info | Database | AceView | gene | 1F342 | |||||
WormQTL | gene | WBGene00019771 | |||||||
WormFlux | gene | WBGene00019771 | |||||||
NDB | locus_tag | CELE_M04F3.5 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00019771|UniProtKB=A0A1C3NSH3 | |||||||
family | PTHR15708 | ||||||||
NCBI | gene | 172093 | |||||||
RefSeq | protein | NM_001330926.5 | |||||||
NM_059047.8 | |||||||||
TrEMBL | UniProtAcc | A0A1C3NSH3 | |||||||
Q95Y95 | |||||||||
UniProt_GCRP | UniProtAcc | A0A1C3NSH3 | |||||||
OMIM | gene | 616951 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Allele (163) | |||||||||
Strain | WBStrain00034757 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (13) | |||||||||
Contained_in_operon | CEOP1970 | ||||||||
Ortholog (42) | |||||||||
Structured_description | Concise_description | M04F3.5 encodes an I-BAR domain-containing protein; upon incubation with multilamellar vesicles, the I-BAR domain of M04F5.3 binds the inner membrane leaflet and inserts an amphipathic alpha helix into the bilayer to effect clustering of PI(4,5)P2 and formation of outwardly facing tubules of characteristic diameter; when expressed in U2OS cells, the M04F5.3 I-BAR domain localizes to filopodia and forms relatively stable structures, when compared to its mammalian counterpart, within the plasma membrane protrusions. | Paper_evidence | WBPaper00032499 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 01 May 2009 00:00:00 | ||||||||
Automated_description | Predicted to enable actin binding activity and phospholipid binding activity. Involved in cell projection assembly and membrane organization. Located in cytoplasmic side of plasma membrane and filopodium. Human ortholog(s) of this gene implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. Is an ortholog of human MTSS2 (MTSS I-BAR domain containing 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0081301 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25094) | ||||
Molecular_info | Corresponding_CDS | M04F3.5a | |||||||
M04F3.5b | |||||||||
Corresponding_CDS_history | M04F3.5:wp86 | ||||||||
Corresponding_transcript | M04F3.5a.1 | ||||||||
M04F3.5b.1 | |||||||||
Other_sequence (23) | |||||||||
Associated_feature | WBsf649118 | ||||||||
WBsf717488 | |||||||||
WBsf717489 | |||||||||
WBsf983487 | |||||||||
WBsf983488 | |||||||||
WBsf1009702 | |||||||||
WBsf1009703 | |||||||||
WBsf219322 | |||||||||
WBsf219323 | |||||||||
Experimental_info | RNAi_result | WBRNAi00117083 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00017182 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00034430 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00050915 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr1027067 | ||||||||
Expr1038554 | |||||||||
Expr1154613 | |||||||||
Expr1200207 | |||||||||
Expr2005208 | |||||||||
Expr2023426 | |||||||||
Drives_construct | WBCnstr00025605 | ||||||||
Construct_product | WBCnstr00025605 | ||||||||
Microarray_results (18) | |||||||||
Expression_cluster (89) | |||||||||
Interaction | WBInteraction000180282 | ||||||||
WBInteraction000245345 | |||||||||
WBInteraction000400675 | |||||||||
WBInteraction000523665 | |||||||||
WBInteraction000545865 | |||||||||
Map_info | Positive | Positive_clone | M04F3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Interpolated_map_position | I | -0.735223 | |||||||
Reference | WBPaper00032499 | ||||||||
WBPaper00038491 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00064339 | |||||||||
Method | Gene |