WormBase Tree Display for Gene: WBGene00019565
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WBGene00019565 | SMap | S_parent | Sequence | K09D9 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name (5) | |||||||||
DB_info | Database | AceView | gene | 5E497 | |||||
WormQTL | gene | WBGene00019565 | |||||||
WormFlux | gene | WBGene00019565 | |||||||
NDB | locus_tag | CELE_K09D9.2 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00019565|UniProtKB=Q9N5I1 | |||||||
family | PTHR24300 | ||||||||
NCBI | gene | 187209 | |||||||
RefSeq | protein | NM_071720.6 | |||||||
TrEMBL | UniProtAcc | Q9N5I1 | |||||||
UniProt_GCRP | UniProtAcc | Q9N5I1 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | cyp-35A3 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cyp | ||||||||
Allele (50) | |||||||||
Strain | WBStrain00032730 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (15) | |||||||||
Ortholog (172) | |||||||||
Paralog (44) | |||||||||
Structured_description | Concise_description | cyp-35A3 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; in addition, cyp-35A(RNAi) also results in a reduction of fat content; cyp-35A3 reporter gene fusions are strongly expressed in the intestine following treatment with xenobiotics. | Paper_evidence | WBPaper00005655 | |||||
WBPaper00025207 | |||||||||
WBPaper00029387 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 26 Feb 2009 00:00:00 | ||||||||
Automated_description | Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (42) | ||||||||
Molecular_info | Corresponding_CDS | K09D9.2 | |||||||
Corresponding_transcript | K09D9.2.1 | ||||||||
Other_sequence | EY459839.1 | ||||||||
Associated_feature (3) | |||||||||
Experimental_info | RNAi_result (15) | ||||||||
Expr_pattern | Expr4664 | ||||||||
Expr1038451 | |||||||||
Expr1154117 | |||||||||
Expr2010736 | |||||||||
Expr2028973 | |||||||||
Drives_construct | WBCnstr00012158 | ||||||||
WBCnstr00025764 | |||||||||
Construct_product | WBCnstr00025764 | ||||||||
Microarray_results (15) | |||||||||
Expression_cluster (296) | |||||||||
Interaction (28) | |||||||||
Map_info | Map | V | Position | -7.01998 | Error | 0.006429 | |||
Positive | Positive_clone | K09D9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (16) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |