WormBase Tree Display for Gene: WBGene00019305
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| WBGene00019305 | SMap | S_parent | Sequence | K02D10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | snap-29 | Person_evidence | WBPerson360 | |||||
| Sequence_name | K02D10.5 | ||||||||
| Molecular_name | K02D10.5 | ||||||||
| K02D10.5.1 | |||||||||
| CE17152 | |||||||||
| Other_name | phi-28 | Person_evidence | WBPerson2582 | ||||||
| CELE_K02D10.5 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | snap-29 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 21 Jul 2009 14:43:34 | WBPerson2970 | Name_change | Other_name | phi-28 | ||||
| 3 | 21 Jul 2009 15:00:53 | WBPerson9133 | Name_change | CGC_name | snap-29 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | snap | ||||||||
| Allele (18) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Contained_in_operon | CEOP3540 | ||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00004364 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006454 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | snap-29 encodes one of the SNAP25-family of double SNARE-domain target-SNAREs orthologous to human synaptosomal-Associated protein (OMIM:604202); snap-29 is an essential gene important for development and cellular functions throughout the life cycle; SNAP-29 is required for secretion of many transmembrane cargo proteins of oocyte cells; loss of SNAP-29 leads to defects in ovulation and RNAi leads to defects in maturation of distal oocytes; SNAP-29 is involved in membrane transport; SNAP-29 regulates LIN-3/EGF secretion in the oocyte which is essential for ovulation; SNAP-29 is expressed in excretory canal, gland cells, hypodermis, vulva, coelomocyte, intestine, gonad sheath cells and some neurons. | Paper_evidence | WBPaper00038394 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 03 Jun 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in intracellular protein transmembrane transport; ovulation; and secretion. Located in apical plasma membrane and recycling endosome. Expressed in several structures, including coelomocyte; excretory canal; gland cell; hermaphrodite somatic gonadal cell; and vulva. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in CEDNIK syndrome. Is an ortholog of human SNAP29 (synaptosome associated protein 29). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:0060337 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11133) | |||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including SNAP29 (synaptosomal-associated protein, 29kDa); the C. elegans ortholog snap-29 is an essential gene required for pre-meiotic maturation of oocytes, proper embryonic cytokinesis, exocytosis in intestinal epethelial cells, and autophagosome maturation; mutant phenotypes of snap-29 include intestinal epithelial cell secretion defects, sterility associated with endomitotic oocytes and pre-mitotic maturation of oocytes, and abnormal localization of phospholipid membrane components. | Homo sapiens | Paper_evidence | WBPaper00047004 | |||||
| WBPaper00038394 | |||||||||
| WBPaper00046045 | |||||||||
| WBPaper00038454 | |||||||||
| Accession_evidence | OMIM | 609528 | |||||||
| 604202 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000376 | ||||||||
| Molecular_info | Corresponding_CDS | K02D10.5 | |||||||
| Corresponding_transcript | K02D10.5.1 | ||||||||
| Other_sequence (52) | |||||||||
| Associated_feature | WBsf225469 | ||||||||
| WBsf225470 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr2016 | ||||||||
| Expr9297 | |||||||||
| Expr9331 | |||||||||
| Expr12078 | |||||||||
| Expr13679 | |||||||||
| Expr1024077 | |||||||||
| Expr1038344 | |||||||||
| Expr1153413 | |||||||||
| Expr2015938 | |||||||||
| Expr2034171 | |||||||||
| Drives_construct | WBCnstr00008649 | ||||||||
| WBCnstr00013881 | |||||||||
| WBCnstr00013907 | |||||||||
| WBCnstr00025928 | |||||||||
| Construct_product | WBCnstr00008288 | ||||||||
| WBCnstr00008649 | |||||||||
| WBCnstr00008683 | |||||||||
| WBCnstr00008687 | |||||||||
| WBCnstr00013881 | |||||||||
| WBCnstr00019923 | |||||||||
| WBCnstr00019924 | |||||||||
| WBCnstr00020162 | |||||||||
| WBCnstr00025928 | |||||||||
| Antibody | WBAntibody00002230 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (93) | |||||||||
| Interaction (54) | |||||||||
| Map_info | Map | III | Position | -0.054542 | Error | 0.001261 | |||
| Positive | Positive_clone | K02D10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
