WormBase Tree Display for Gene: WBGene00019166
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| WBGene00019166 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | tat-2 | |||||||
| Sequence_name | H06H21.10 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | CELE_H06H21.10 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | tat-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 15 Sep 2004 16:45:49 | WBPerson1971 | Name_change | CGC_name | tat-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tat | ||||||||
| Allele (262) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (66) | |||||||||
| Paralog | WBGene00009498 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00012360 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013034 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00017174 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020784 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | tat-2 encodes one of six C. elegans subfamily IV P-type ATPase that, by sequence similarity, is proposed to function as an aminophospholipid translocase (flippase); genetic analyses show that tat-2 has two distinct functions in lipid metabolism: 1) tat-2 is essential for reproductive growth under conditions of sterol deprivation, and 2) TAT-2 activity in the intestine plays a role in regulating monomethyl branched-chain fatty acid-mediated functions during postembryonic growth and development; a tat-2::gfp promoter fusion is expressed beginning at the two-fold stage of embryogenesis and continuing through adulthood with expression detected in pharyngeal cells, the intestine, rectal gland cells, the excretory system, the primary vulval lineages, and the gonad. | Paper_evidence | WBPaper00032240 | |||||
| WBPaper00035064 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Aug 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in sterol metabolic process. Predicted to be located in plasma membrane and trans-Golgi network. Expressed in several structures, including excretory system; gonad; pharynx; rectal gland cell; and vulva. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Is an ortholog of human ATP8B4 (ATPase phospholipid transporting 8B4 (putative)). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070226 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3706) | ||||
| DOID:0070228 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3706) | ||||||
| DOID:0070231 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3706) | ||||||
| DOID:1852 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3706) | ||||||
| Molecular_info | Corresponding_CDS | H06H21.10a | |||||||
| H06H21.10b | |||||||||
| H06H21.10c | |||||||||
| H06H21.10d | |||||||||
| H06H21.10e | |||||||||
| H06H21.10f | |||||||||
| Corresponding_CDS_history | H06H21.10a:wp225 | ||||||||
| H06H21.10b:wp239 | |||||||||
| Corresponding_transcript | H06H21.10a.1 | ||||||||
| H06H21.10b.1 | |||||||||
| H06H21.10c.1 | |||||||||
| H06H21.10d.1 | |||||||||
| H06H21.10e.1 | |||||||||
| H06H21.10f.1 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf718081 | ||||||||
| WBsf718082 | |||||||||
| WBsf718083 | |||||||||
| WBsf996401 | |||||||||
| WBsf230028 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00099121 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00049310 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092580 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00016205 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092587 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077713 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00078011 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097532 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00003133 | ||||||||
| WBCnstr00005398 | |||||||||
| WBCnstr00015000 | |||||||||
| WBCnstr00022881 | |||||||||
| Construct_product | WBCnstr00015000 | ||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (233) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | IV | Position | 1.35848 | |||||
| Positive | Positive_clone | H06H21 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4954 | |||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
