WormBase Tree Display for Gene: WBGene00018604
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| WBGene00018604 | SMap | S_parent | Sequence | F48E3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | uggt-1 | Paper_evidence | WBPaper00040397 | |||||
| Person_evidence | WBPerson12962 | ||||||||
| Sequence_name | F48E3.3 | ||||||||
| Molecular_name (3) | |||||||||
| Other_name | CELE_F48E3.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | uggt-1 | ||||||||
| DB_info | Database | AceView | gene | XI114 | |||||
| WormQTL | gene | WBGene00018604 | |||||||
| WormFlux | gene | WBGene00018604 | |||||||
| NDB | locus_tag | CELE_F48E3.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00018604|UniProtKB=Q9GPA0 | |||||||
| family | PTHR11226 | ||||||||
| NCBI | gene | 181007 | |||||||
| RefSeq | protein | NM_076867.5 | |||||||
| TREEFAM | TREEFAM_ID | TF300320 | |||||||
| TrEMBL | UniProtAcc | Q9GPA0 | |||||||
| UniProt_GCRP | UniProtAcc | Q9GPA0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 11 Nov 2011 16:17:07 | WBPerson2970 | Name_change | CGC_name | uggt-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | uggt | ||||||||
| Allele (89) | |||||||||
| Strain | WBStrain00002539 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00009178 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | uggt-1 encodes one of two C. elegans homologs of UDP-Glc:glycoprotein glucosyltransferase (UGGT), an endoplasmic reticulum enzyme involved in quality control of glycoprotein folding; expression of uggt-1 in S. pombe cells lacking functional UGGT activity indicates that UGGT-1 displays UDP-Glc:glycoprotein glucosyltransferase activity; loss of uggt-1 activity via RNAi results in larval developmental delay and a shortened lifespan; uggt-1 is expressed throughout larval development, with peak levels seen at the L2/L3 stages, and uggt-1 expression is upregulated in an ire-1-dependent manner in response to endoplasmic reticulum stress; a uggt-1::gfp promoter fusion is expressed in the nervous system, including the amphid and phasmid neurons, the nerve ring, and the dorsal and ventral nerve cords. | Paper_evidence | WBPaper00040397 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Nov 2011 00:00:00 | ||||||||
| Automated_description | Enables UDP-glucose:glycoprotein glucosyltransferase activity. Involved in IRE1-mediated unfolded protein response; protein N-linked glycosylation via asparagine; and regulation of nematode larval development. Predicted to be located in endoplasmic reticulum. Expressed in several structures, including anal depressor muscle; germ line; neurons; pharyngeal-intestinal valve; and rectal gland cell. Is an ortholog of human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1) and UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F48E3.3 | |||||||
| Corresponding_transcript | F48E3.3.1 | ||||||||
| Other_sequence (62) | |||||||||
| Associated_feature | WBsf654142 | ||||||||
| WBsf670729 | |||||||||
| WBsf670730 | |||||||||
| WBsf237582 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00003112 | ||||||||
| WBCnstr00004548 | |||||||||
| WBCnstr00014223 | |||||||||
| WBCnstr00026387 | |||||||||
| WBCnstr00041864 | |||||||||
| Construct_product | WBCnstr00026387 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (171) | |||||||||
| Interaction (81) | |||||||||
| Map_info | Map | X | Position | -1.66215 | |||||
| Positive | Positive_clone | F48E3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (10) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
