WormBase Tree Display for Gene: WBGene00018334

WBGene00018334 SMap: S_parent: Sequence: F42A9
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (33)
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (72)
    Paralog (44)
    Structured_description: Concise_description: cyp-33E2 encodes a cytochrome P450; when co-expressed with human CPR in vitro, CYP-33E2 exhibits monooxygenase activity on a variety of long-chain fatty acid substrates, including eicosapentaenoic acid and arachidonic acid; cyp-33E2(RNAi) animals show reduced rates of pharyngeal pumping, suggesting that CYP-33E2-generated metabolites may play a role in regulating pharyngeal muscle contraction; a cyp-33E2::GFP reporter fusion is expressed in the pharynx, particularly in the pharyngeal marginal cells, throughout larval development and adulthood. Paper_evidence: WBPaper00038127
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Feb 2011 00:00:00
      Automated_description: Enables monooxygenase activity. Involved in long-chain fatty acid metabolic process and regulation of pharyngeal pumping. Located in intracellular membrane-bounded organelle. Expressed in pharynx. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Is an ortholog of human CYP2C8 (cytochrome P450 family 2 subfamily C member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:783 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2622)
      DOID:1073 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2622)
  Molecular_info: Corresponding_CDS: F42A9.5
    Corresponding_CDS_history: F42A9.5:wp185
    Corresponding_transcript: F42A9.5.1
      F42A9.5.2
      F42A9.5.3
    Other_sequence: GR12232
      OOC00987_1
      FC540690.1
      Oden_isotig25521
      BUC01742_1
      BXC03257_1
      GRC01039_1
      CJC14474_1
      BXC02717_1
      ACC26323_1
    Associated_feature (6)
  Experimental_info: RNAi_result: WBRNAi00078662 Inferred_automatically: RNAi_primary
      WBRNAi00078574 Inferred_automatically: RNAi_primary
      WBRNAi00110282 Inferred_automatically: RNAi_primary
      WBRNAi00014810 Inferred_automatically: RNAi_primary
      WBRNAi00032128 Inferred_automatically: RNAi_primary
      WBRNAi00110653 Inferred_automatically: RNAi_primary
      WBRNAi00047078 Inferred_automatically: RNAi_primary
      WBRNAi00092669 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11526
      Expr1019180
      Expr1150943
      Expr2010724
      Expr2028962
    Drives_construct: WBCnstr00019058
      WBCnstr00026605
    Construct_product: WBCnstr00026605
    Microarray_results (19)
    Expression_cluster (150)
    Interaction (35)
  Map_info: Map: IV Position: 3.90891 Error: 0.001424
    Positive: Positive_clone: F42A9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene