WormBase Tree Display for Gene: WBGene00017920
expand all nodes | collapse all nodes | view schema
WBGene00017920 | SMap | S_parent | Sequence | F29B9 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | jmjd-1.2 | Person_evidence | WBPerson260 | |||
Sequence_name | F29B9.2 | ||||||
Molecular_name | F29B9.2a | ||||||
F29B9.2a.1 | |||||||
CE09781 | |||||||
F29B9.2b | |||||||
CE27145 | |||||||
F29B9.2c | |||||||
CE48643 | |||||||
F29B9.2b.1 | |||||||
F29B9.2c.1 | |||||||
Other_name (2) | |||||||
Public_name | jmjd-1.2 | ||||||
DB_info | Database (14) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | jmjd | ||||||
Allele (59) | |||||||
Strain | WBStrain00037581 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (31) | |||||||
Contained_in_operon | CEOP4136 | ||||||
Ortholog (45) | |||||||
Paralog | WBGene00005013 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00020821 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | jmjd-1.2 encodes a PHD and JmjC domain-containing histone demethylase that is homologous to human PHF8, mutations in which are associated with mild X-linked mental retardation (XLMR) and cleft/lip palate; JMJD-1.2 exhibits H3K9me2 and H3K27me2 demethylase activity in vitro and loss-of-function mutations in jmjd-1.2 result in increased levels of H3K9me2 and H3K27me2 in protein lysates from mutant animals; jmjd-1.2 mutant animals also exhibit locomotion defects with increased wavelength, but normal amplitude, of sinusoidal movement; a jmjd-1.2::GFP fusion protein is strongly expressed in neurons where it localizes to the nucleus; fainter expression is also seen in muscle, intestine, and hypodermal cells; jmjd-1.2 expression in neurons is sufficient to rescue the locomotion defects. | Paper_evidence | WBPaper00036110 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 08 Apr 2010 00:00:00 | ||||||
Automated_description | Enables histone H3K27me2/H3K27me3 demethylase activity; histone H3K9 demethylase activity; and histone binding activity. Involved in mitochondrial unfolded protein response. Located in nucleus. Expressed in several structures, including germ cell; hypodermis; muscle cell; and neurons. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in melanoma; prostate cancer; and syndromic X-linked intellectual disability Siderius type. Is an ortholog of human KDM7A (lysine demethylase 7A). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:0060309 | Homo sapiens | Paper_evidence | WBPaper00050709 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 13 Nov 2017 00:00:00 | ||||||
Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20672) | |||
DOID:1909 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:22224) | ||||
DOID:0060812 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20672) | ||||
Models_disease_asserted | WBDOannot00000447 | ||||||
Molecular_info | Corresponding_CDS | F29B9.2a | |||||
F29B9.2b | |||||||
F29B9.2c | |||||||
Corresponding_transcript | F29B9.2a.1 | ||||||
F29B9.2b.1 | |||||||
F29B9.2c.1 | |||||||
Other_sequence (65) | |||||||
Associated_feature | WBsf047593 | ||||||
WBsf047594 | |||||||
WBsf645943 | |||||||
WBsf977089 | |||||||
WBsf996358 | |||||||
WBsf228223 | |||||||
WBsf228224 | |||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern | Expr13259 | ||||||
Expr13525 | |||||||
Expr1021912 | |||||||
Expr1037705 | |||||||
Expr1149803 | |||||||
Expr2012886 | |||||||
Expr2031120 | |||||||
Drives_construct | WBCnstr00026915 | ||||||
Construct_product | WBCnstr00026915 | ||||||
Regulate_expr_cluster | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated | ||||||
WBPaper00049545:rgef-1pjmjd-1.2(+)_downregulated | |||||||
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated | |||||||
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated | |||||||
WBPaper00050709:jmjd-1.2(tm3713)_regulated | |||||||
WBPaper00062156:jmjd-1.2(zr1010)_downregulated | |||||||
WBPaper00062156:jmjd-1.2(zr1010)_upregulated | |||||||
WBPaper00066083:hlh-17p-jmjd-1.2_downregulated | |||||||
WBPaper00066083:hlh-17p-jmjd-1.2_upregulated | |||||||
Antibody | WBAntibody00002197 | ||||||
WBAntibody00002746 | |||||||
Microarray_results (27) | |||||||
Expression_cluster (115) | |||||||
Interaction (18) | |||||||
Map_info | Map | IV | Position | 0.6425 | Error | 0.013666 | |
Positive | Positive_clone | F29B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (18) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |