WormBase Tree Display for Gene: WBGene00017699
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WBGene00017699 | SMap | S_parent | Sequence | F22D3 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | flcn-1 | Person_evidence | WBPerson15935 | |||
Sequence_name | F22D3.2 | ||||||
Molecular_name (21) | |||||||
Other_name | CELE_F22D3.2 | Accession_evidence | NDB | BX284602 | |||
Public_name | flcn-1 | ||||||
DB_info | Database | AceView | gene | 2H237 | |||
WormQTL | gene | WBGene00017699 | |||||
WormFlux | gene | WBGene00017699 | |||||
OMIM | disease | 135150 | |||||
gene | 607273 | ||||||
NDB | locus_tag | CELE_F22D3.2 | |||||
Panther | gene | CAEEL|WormBase=WBGene00017699|UniProtKB=H2KY80 | |||||
family | PTHR31441 | ||||||
NCBI | gene | 174134 | |||||
RefSeq | protein | NM_001306549.4 | |||||
NM_001330952.3 | |||||||
NM_001276732.2 | |||||||
NM_001381469.1 | |||||||
NM_001306551.3 | |||||||
NM_001381470.1 | |||||||
NM_001026937.5 | |||||||
TrEMBL | UniProtAcc | S6FCY3 | |||||
S6EZM3 | |||||||
K0M7B5 | |||||||
J7S130 | |||||||
S6F533 | |||||||
Q5DX40 | |||||||
S6FMZ4 | |||||||
UniProt_GCRP | UniProtAcc | S6FMZ4 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | flcn | ||||||
Allele (252) | |||||||
Strain | WBStrain00031743 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (40) | |||||||
Structured_description | Concise_description | F22D3.2 encodes an ortholog of human folliculin (OMIM:607273, mutated inBirt-Hogg-Dube syndrome). | Paper_evidence | WBPaper00028837 | |||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 11 Dec 2006 00:00:00 | ||||||
Automated_description | Predicted to contribute to GTPase activator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of TORC1 signaling; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol. Expressed in excretory cell; nervous system; spermatheca; and vulva. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in several diseases, including Birt-Hogg-Dube syndrome; primary spontaneous pneumothorax; and renal cell carcinoma. Is an ortholog of human FLCN (folliculin). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:0050676 | Homo sapiens | Paper_evidence | WBPaper00048631 | ||
Accession_evidence | OMIM | 135150 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 03 Nov 2015 00:00:00 | ||||||
Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | |||
DOID:0080218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | ||||
DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | ||||
DOID:0050676 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | ||||
Models_disease_in_annotation | WBDOannot00000382 | ||||||
Molecular_info | Corresponding_CDS | F22D3.2c | |||||
F22D3.2d | |||||||
F22D3.2e | |||||||
F22D3.2f | |||||||
F22D3.2g | |||||||
F22D3.2i | |||||||
F22D3.2j | |||||||
Corresponding_CDS_history | F22D3.2:wp127 | ||||||
F22D3.2a:wp206 | |||||||
F22D3.2a:wp238 | |||||||
F22D3.2a:wp274 | |||||||
F22D3.2b:wp206 | |||||||
F22D3.2b:wp238 | |||||||
F22D3.2h:wp274 | |||||||
Corresponding_transcript | F22D3.2c.1 | ||||||
F22D3.2d.1 | |||||||
F22D3.2e.1 | |||||||
F22D3.2f.1 | |||||||
F22D3.2g.1 | |||||||
F22D3.2i.1 | |||||||
F22D3.2j.1 | |||||||
Other_sequence (21) | |||||||
Associated_feature (63) | |||||||
Experimental_info | RNAi_result | WBRNAi00013748 | Inferred_automatically | RNAi_primary | |||
WBRNAi00045306 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00013747 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00031265 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00092437 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00092428 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr10985 | ||||||
Expr13864 | |||||||
Expr1017397 | |||||||
Expr1037596 | |||||||
Expr1149230 | |||||||
Expr2011814 | |||||||
Expr2030052 | |||||||
Drives_construct | WBCnstr00017598 | ||||||
WBCnstr00017614 | |||||||
WBCnstr00027093 | |||||||
Construct_product | WBCnstr00017614 | ||||||
WBCnstr00027093 | |||||||
WBCnstr00040219 | |||||||
Regulate_expr_cluster | WBPaper00042236:flcn-1(ok975)_upregulated | ||||||
WBPaper00056471:flcn-1(ok975)_downregulated | |||||||
WBPaper00056471:flcn-1(ok975)_upregulated | |||||||
Antibody | WBAntibody00002522 | ||||||
Microarray_results (41) | |||||||
Expression_cluster (164) | |||||||
Interaction | WBInteraction000402369 | ||||||
WBInteraction000520210 | |||||||
WBInteraction000520211 | |||||||
WBInteraction000520212 | |||||||
WBInteraction000520213 | |||||||
WBInteraction000520218 | |||||||
WBInteraction000521811 | |||||||
WBInteraction000534849 | |||||||
Map_info | Map | II | Position | 0.145905 | |||
Positive | Positive_clone | F22D3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (10) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |