WormBase Tree Display for Gene: WBGene00017123
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WBGene00017123 | SMap | S_parent | Sequence | E04F6 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | maoc | ||||||
Allele (21) | |||||||
Strain | WBStrain00032684 | ||||||
WBStrain00040194 | |||||||
WBStrain00040195 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Ortholog (40) | |||||||
Structured_description | Concise_description | maoc-1 encodes an ortholog of human HSD17B4 (OMIM:601860, mutated in D-bifunctional protein deficiency); MAOC-1 contains a MaoC-like domain found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit) and by homology, is predicted to function in peroxisomal fatty acid beta-oxidation; loss of maoc-1 activity via RNAi results in lifespan extension, increased fat content, and an increased susceptibility to pathogens. | Paper_evidence | WBPaper00005655 | |||
WBPaper00013529 | |||||||
WBPaper00026715 | |||||||
WBPaper00028482 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 16 Dec 2007 00:00:00 | ||||||
Automated_description | Enables identical protein binding activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in peroxisomal membrane. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Is an ortholog of human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00035972 | ||
Curator_confirmed | WBPerson38202 | ||||||
Date_last_updated | 29 Jun 2018 00:00:00 | ||||||
Potential_model (3) | |||||||
Models_disease_asserted | WBDOannot00000569 | ||||||
Molecular_info | Corresponding_CDS | E04F6.3 | |||||
Corresponding_transcript | E04F6.3.1 | ||||||
Other_sequence (73) | |||||||
Associated_feature | WBsf644358 | ||||||
WBsf221572 | |||||||
Experimental_info | RNAi_result | WBRNAi00065091 | Inferred_automatically | RNAi_primary | |||
WBRNAi00063963 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00012692 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00108443 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00080807 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00023398 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00030502 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00043682 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00063964 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr12049 | ||||||
Expr13909 | |||||||
Expr1016601 | |||||||
Expr1037356 | |||||||
Expr1147666 | |||||||
Expr2013373 | |||||||
Expr2031605 | |||||||
Drives_construct | WBCnstr00020137 | ||||||
WBCnstr00027554 | |||||||
WBCnstr00040240 | |||||||
Construct_product | WBCnstr00020137 | ||||||
WBCnstr00023003 | |||||||
WBCnstr00027554 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (200) | |||||||
Interaction (23) | |||||||
Map_info | Map | II | Position | 0.498761 | Error | 7.7e-05 | |
Positive | Positive_clone | E04F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (19) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |