WormBase Tree Display for Gene: WBGene00017066
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WBGene00017066 | SMap | S_parent | Sequence | D2092 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | maco-1 | Paper_evidence | WBPaper00038258 | |||
Person_evidence | WBPerson724 | ||||||
Sequence_name | D2092.5 | ||||||
Molecular_name (3) | |||||||
Other_name | CELE_D2092.5 | Accession_evidence | NDB | BX284601 | |||
Public_name | maco-1 | ||||||
DB_info | Database | AceView | gene | 1H170 | |||
WormQTL | gene | WBGene00017066 | |||||
WormFlux | gene | WBGene00017066 | |||||
NDB | locus_tag | CELE_D2092.5 | |||||
Panther | gene | CAEEL|WormBase=WBGene00017066|UniProtKB=P91193 | |||||
family | PTHR13289 | ||||||
NCBI | gene | 183963 | |||||
RefSeq | protein | NM_059501.7 | |||||
SwissProt | UniProtAcc | P91193 | |||||
TREEFAM | TREEFAM_ID | TF324023 | |||||
UniProt_GCRP | UniProtAcc | P91193 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | maco | ||||||
Allele (80) | |||||||
Strain | WBStrain00033005 | ||||||
WBStrain00022012 | |||||||
WBStrain00022013 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (37) | |||||||
Structured_description | Concise_description | maco-1 encodes a novel protein with five transmembrane domains in the N-terminus and four coiled coil domains in the C-terminus; maco-1 is functionally conserved across species and is orthologous to human macoilin (OMIM:601301); macoilin is involved in assembly or traffic of ion channels or ion channel regulators; MACO-1 is not required for development but for appropriate regulation of neuronal activity; both transmembrane domains and coiled coil domains are required for appropriate function of MACO-1; proper function of MACO-1 is necessary for normal thermotaxis in many neurons; mutations in C. elegans macoilin disrupt aggregation and are associated with multiple behavioral defects; MACO-1 is localized to the rough ER of neurons; MACO-1 is also restricted to neuronal cell bodies at embryonic developmental stages. | Paper_evidence | WBPaper00038258 | |||
WBPaper00038428 | |||||||
Curator_confirmed | WBPerson12884 | ||||||
Date_last_updated | 15 Jul 2011 00:00:00 | ||||||
Automated_description | Predicted to enable microtubule binding activity. Involved in chemotaxis; neuronal signal transduction; and thermotaxis. Located in neuronal cell body; nuclear envelope; and rough endoplasmic reticulum. Expressed in epithelial cell; muscle cell; and nervous system. Is an ortholog of human MACO1 (macoilin 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | D2092.5 | |||||
Corresponding_CDS_history | D2092.5:wp154 | ||||||
D2092.5:wp221 | |||||||
Corresponding_transcript | D2092.5.1 | ||||||
Other_sequence | CRC06233_1 | ||||||
Oden_isotig19062 | |||||||
CR10623 | |||||||
CJC09089_1 | |||||||
Associated_feature (11) | |||||||
Experimental_info | RNAi_result | WBRNAi00043519 | Inferred_automatically | RNAi_primary | |||
WBRNAi00043518 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00007973 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00003295 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00116562 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (12) | |||||||
Drives_construct | WBCnstr00013794 | ||||||
WBCnstr00013887 | |||||||
WBCnstr00013888 | |||||||
WBCnstr00018769 | |||||||
WBCnstr00027595 | |||||||
Construct_product | WBCnstr00013794 | ||||||
WBCnstr00013888 | |||||||
WBCnstr00021857 | |||||||
WBCnstr00027595 | |||||||
Antibody | WBAntibody00002220 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (112) | |||||||
Interaction | WBInteraction000253192 | ||||||
WBInteraction000303978 | |||||||
WBInteraction000323592 | |||||||
WBInteraction000443269 | |||||||
WBProcess | WBbiopr:00000025 | ||||||
Map_info | Map | I | Position | 1.23755 | Error | 0.004358 | |
Positive | Positive_clone | D2092 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (11) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |