WormBase Tree Display for Gene: WBGene00017066
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WBGene00017066 | SMap | S_parent | Sequence | D2092 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name (5) | |||||||||
DB_info | Database (10) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 06 Apr 2011 14:40:30 | WBPerson2970 | Name_change | CGC_name | maco-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | maco | ||||||||
Allele (80) | |||||||||
Strain | WBStrain00033005 | ||||||||
WBStrain00022012 | |||||||||
WBStrain00022013 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (37) | |||||||||
Structured_description | Concise_description | maco-1 encodes a novel protein with five transmembrane domains in the N-terminus and four coiled coil domains in the C-terminus; maco-1 is functionally conserved across species and is orthologous to human macoilin (OMIM:601301); macoilin is involved in assembly or traffic of ion channels or ion channel regulators; MACO-1 is not required for development but for appropriate regulation of neuronal activity; both transmembrane domains and coiled coil domains are required for appropriate function of MACO-1; proper function of MACO-1 is necessary for normal thermotaxis in many neurons; mutations in C. elegans macoilin disrupt aggregation and are associated with multiple behavioral defects; MACO-1 is localized to the rough ER of neurons; MACO-1 is also restricted to neuronal cell bodies at embryonic developmental stages. | Paper_evidence | WBPaper00038258 | |||||
WBPaper00038428 | |||||||||
Curator_confirmed | WBPerson12884 | ||||||||
Date_last_updated | 15 Jul 2011 00:00:00 | ||||||||
Automated_description | Predicted to enable microtubule binding activity. Involved in chemotaxis; neuronal signal transduction; and thermotaxis. Located in neuronal cell body; nuclear envelope; and rough endoplasmic reticulum. Expressed in epithelial cell; muscle cell; and nervous system. Is an ortholog of human MACO1 (macoilin 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | D2092.5 | |||||||
Corresponding_CDS_history | D2092.5:wp154 | ||||||||
D2092.5:wp221 | |||||||||
Corresponding_transcript | D2092.5.1 | ||||||||
Other_sequence | CRC06233_1 | ||||||||
Oden_isotig19062 | |||||||||
CR10623 | |||||||||
CJC09089_1 | |||||||||
Associated_feature (11) | |||||||||
Experimental_info | RNAi_result | WBRNAi00043519 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00043518 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00007973 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00003295 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00116562 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (12) | |||||||||
Drives_construct | WBCnstr00013794 | ||||||||
WBCnstr00013887 | |||||||||
WBCnstr00013888 | |||||||||
WBCnstr00018769 | |||||||||
WBCnstr00027595 | |||||||||
Construct_product | WBCnstr00013794 | ||||||||
WBCnstr00013888 | |||||||||
WBCnstr00021857 | |||||||||
WBCnstr00027595 | |||||||||
Antibody | WBAntibody00002220 | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (112) | |||||||||
Interaction | WBInteraction000253192 | ||||||||
WBInteraction000303978 | |||||||||
WBInteraction000323592 | |||||||||
WBInteraction000443269 | |||||||||
WBProcess | WBbiopr:00000025 | ||||||||
Map_info | Map | I | Position | 1.23755 | Error | 0.004358 | |||
Positive | Positive_clone | D2092 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (11) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |