WormBase Tree Display for Gene: WBGene00016192
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WBGene00016192 | SMap | S_parent | Sequence | C28H8 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | bcl-7 | Person_evidence | WBPerson426 | |||
Sequence_name | C28H8.1 | ||||||
Molecular_name | C28H8.1 | ||||||
C28H8.1.1 | |||||||
CE01820 | |||||||
Other_name | CELE_C28H8.1 | Accession_evidence | NDB | BX284603 | |||
Public_name | bcl-7 | ||||||
DB_info | Database | AceView | gene | 3H17 | |||
WormQTL | gene | WBGene00016192 | |||||
WormFlux | gene | WBGene00016192 | |||||
NDB | locus_tag | CELE_C28H8.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00016192|UniProtKB=Q09242 | |||||
family | PTHR12767 | ||||||
NCBI | gene | 175838 | |||||
RefSeq | protein | NM_065886.6 | |||||
SwissProt | UniProtAcc | Q09242 | |||||
TREEFAM | TREEFAM_ID | TF317441 | |||||
UniProt_GCRP | UniProtAcc | Q09242 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | bcl | ||||||
Allele (15) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00053020 | ||||||
00053021 | |||||||
00053022 | |||||||
00053023 | |||||||
00053024 | |||||||
Ortholog (43) | |||||||
Structured_description | Concise_description | bcl-7 encodes the sole C. elegans member of the BCL7 family of proteins that contains human proteins, namely BCL7A and BCL7B, that are associated with malignant diseases; bcl-7 activity is required for proper terminal seam cell differentiation as well as for normal development of the distal tip cells of the somatic gonad and germ line; in controlling cell development and differentiation, bcl-7 interacts with the Wnt signaling pathway, regulating the asymmetric localization of WRM-1, and hence POP-1, in asymmetric cell divisions; bcl-7 may also function to regulate apoptosis, as loss of bcl-7 activity results in increased expression of ced-9; a BCL-7::GFP reporter is expressed ubiquitously and localized to nuclei; mammalian BCL7 family members are members of Swi/Snf transcriptional regulatory complexes. | Paper_evidence | WBPaper00046304 | |||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 20 May 2014 00:00:00 | ||||||
Automated_description | Predicted to be involved in Wnt signaling pathway; apoptotic process; and cell differentiation. Predicted to be located in nucleus. Expressed in distal tip cell; germ cell; and gonadal sheath cell. Is an ortholog of human BCL7A (BAF chromatin remodeling complex subunit BCL7A). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C28H8.1 | |||||
Corresponding_transcript | C28H8.1.1 | ||||||
Other_sequence | Acan_isotig14735 | ||||||
Oden_isotig13379 | |||||||
CBC13479_1 | |||||||
Tcir_isotig09201 | |||||||
CJC05531_1 | |||||||
Dviv_isotig33085 | |||||||
Tcol_contig20712 | |||||||
Oden_isotig13380 | |||||||
JI180958.1 | |||||||
Associated_feature | WBsf645222 | ||||||
WBsf645223 | |||||||
WBsf225029 | |||||||
Experimental_info | RNAi_result | WBRNAi00061740 | Inferred_automatically | RNAi_primary | |||
WBRNAi00114621 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00029301 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00011309 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005962 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00076175 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00041425 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr12126 | ||||||
Expr1015868 | |||||||
Expr1036929 | |||||||
Expr1145455 | |||||||
Expr2009584 | |||||||
Expr2027821 | |||||||
Drives_construct | WBCnstr00008715 | ||||||
WBCnstr00020228 | |||||||
WBCnstr00020229 | |||||||
WBCnstr00028256 | |||||||
Construct_product (4) | |||||||
Microarray_results (21) | |||||||
Expression_cluster (121) | |||||||
Interaction (67) | |||||||
Map_info | Map | III | Position | -1.43385 | |||
Positive | Positive_clone | C28H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00032961 | ||||||
WBPaper00038491 | |||||||
WBPaper00046304 | |||||||
WBPaper00055090 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |