WormBase Tree Display for Gene: WBGene00016103
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WBGene00016103 | SMap | S_parent | Sequence | C25F6 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | dpyd-1 | |||||
Sequence_name | C25F6.3 | ||||||
Molecular_name | C25F6.3 | ||||||
C25F6.3.1 | |||||||
CE38489 | |||||||
Other_name | CELE_C25F6.3 | Accession_evidence | NDB | BX284606 | |||
Public_name | dpyd-1 | ||||||
DB_info | Database (13) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | dpyd | ||||||
Allele (67) | |||||||
Strain | WBStrain00037841 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (23) | |||||||
Ortholog (32) | |||||||
Paralog | WBGene00012326 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00013376 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00020932 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | dpyd-1 encodes the C. elegans ortholog of human DihydroPYrimidine Dehydrogenase (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270); DPYD-1 is the first and rate-limiting enzyme for uracil and thymine metabolism to 5,6-dihydrouracil and 5,6-dihydrothymine, respectively, and in humans, functions in metabolism of the anti-cancer pyrimidine antagonist 5-fluorouracil (5-FU); in C. elegans, loss of dpyd-1 activity via RNAi results in sensitivity (decreased survival) to 5-FU while conversely, DPYD-1 overexpression affords increased germ cell survivability to 5-FU. | Paper_evidence | WBPaper00004637 | |||
WBPaper00013017 | |||||||
WBPaper00031988 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 10 Jul 2008 00:00:00 | ||||||
Automated_description | Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and gallbladder cancer. Is an ortholog of human DPYD (dihydropyrimidine dehydrogenase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (4) | ||||||
Molecular_info | Corresponding_CDS | C25F6.3 | |||||
Corresponding_CDS_history | C25F6.3:wp142 | ||||||
Corresponding_transcript | C25F6.3.1 | ||||||
Other_sequence (74) | |||||||
Associated_feature | WBsf655176 | ||||||
WBsf662790 | |||||||
WBsf1005274 | |||||||
WBsf1022956 | |||||||
WBsf235726 | |||||||
WBsf235727 | |||||||
WBsf235728 | |||||||
Experimental_info | RNAi_result | WBRNAi00041194 | Inferred_automatically | RNAi_primary | |||
Expr_pattern | Expr1024901 | ||||||
Expr1036877 | |||||||
Expr1145225 | |||||||
Expr2011080 | |||||||
Expr2029317 | |||||||
Drives_construct | WBCnstr00028324 | ||||||
Construct_product | WBCnstr00028324 | ||||||
Microarray_results (19) | |||||||
Expression_cluster (191) | |||||||
Interaction (64) | |||||||
Map_info | Map | X | Position | -5.27561 | |||
Positive | Positive_clone | C25F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00013017 | ||||||
WBPaper00031988 | |||||||
WBPaper00038491 | |||||||
WBPaper00049828 | |||||||
WBPaper00055090 | |||||||
WBPaper00056904 | |||||||
WBPaper00062388 | |||||||
WBPaper00065140 | |||||||
WBPaper00065331 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |