WormBase Tree Display for Gene: WBGene00016103
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WBGene00016103 | SMap | S_parent | Sequence | C25F6 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | dpyd | |||||
Allele (67) | ||||||
Strain | WBStrain00037841 | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (23) | ||||||
Ortholog (32) | ||||||
Paralog | WBGene00012326 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||
WBGene00013376 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00020932 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
Structured_description | Concise_description | dpyd-1 encodes the C. elegans ortholog of human DihydroPYrimidine Dehydrogenase (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270); DPYD-1 is the first and rate-limiting enzyme for uracil and thymine metabolism to 5,6-dihydrouracil and 5,6-dihydrothymine, respectively, and in humans, functions in metabolism of the anti-cancer pyrimidine antagonist 5-fluorouracil (5-FU); in C. elegans, loss of dpyd-1 activity via RNAi results in sensitivity (decreased survival) to 5-FU while conversely, DPYD-1 overexpression affords increased germ cell survivability to 5-FU. | Paper_evidence | WBPaper00004637 | ||
WBPaper00013017 | ||||||
WBPaper00031988 | ||||||
Curator_confirmed | WBPerson1843 | |||||
WBPerson1823 | ||||||
WBPerson567 | ||||||
Date_last_updated | 10 Jul 2008 00:00:00 | |||||
Automated_description | Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and gallbladder cancer. Is an ortholog of human DPYD (dihydropyrimidine dehydrogenase). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model (4) | |||||
Molecular_info | Corresponding_CDS | C25F6.3 | ||||
Corresponding_CDS_history | C25F6.3:wp142 | |||||
Corresponding_transcript | C25F6.3.1 | |||||
Other_sequence (74) | ||||||
Associated_feature | WBsf655176 | |||||
WBsf662790 | ||||||
WBsf1005274 | ||||||
WBsf1022956 | ||||||
WBsf235726 | ||||||
WBsf235727 | ||||||
WBsf235728 | ||||||
Experimental_info | RNAi_result | WBRNAi00041194 | Inferred_automatically | RNAi_primary | ||
Expr_pattern | Expr1024901 | |||||
Expr1036877 | ||||||
Expr1145225 | ||||||
Expr2011080 | ||||||
Expr2029317 | ||||||
Drives_construct | WBCnstr00028324 | |||||
Construct_product | WBCnstr00028324 | |||||
Microarray_results (19) | ||||||
Expression_cluster (191) | ||||||
Interaction (64) | ||||||
Map_info | Map | X | Position | -5.27561 | ||
Positive | Positive_clone | C25F6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||
Pseudo_map_position | ||||||
Reference | WBPaper00013017 | |||||
WBPaper00031988 | ||||||
WBPaper00038491 | ||||||
WBPaper00049828 | ||||||
WBPaper00055090 | ||||||
WBPaper00056904 | ||||||
WBPaper00062388 | ||||||
WBPaper00065140 | ||||||
WBPaper00065331 | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |