WormBase Tree Display for Gene: WBGene00015648
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WBGene00015648 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||||
Name | CGC_name | orai-1 | Person_evidence | WBPerson1851 | |||||
Sequence_name | C09F5.2 | ||||||||
Molecular_name | C09F5.2a | ||||||||
C09F5.2a.1 | |||||||||
CE42990 | |||||||||
C09F5.2b | |||||||||
CE01774 | |||||||||
C09F5.2a.2 | |||||||||
C09F5.2b.1 | |||||||||
Other_name | CELE_C09F5.2 | Accession_evidence | NDB | BX284603 | |||||
Public_name | orai-1 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 18 Jul 2006 14:35:12 | WBPerson2970 | Name_change | CGC_name | orai-1 | ||||
3 | 03 Nov 2008 13:42:45 | WBPerson1867 | Event | Acquires_merge | WBGene00021065 | ||||
Acquires_merge | WBGene00021065 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | orai | ||||||||
Allele (179) | |||||||||
Strain | WBStrain00002066 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (16) | |||||||||
Contained_in_operon | CEOP3859 | ||||||||
Ortholog (46) | |||||||||
Structured_description | Concise_description | orai-1 encodes a calcium release activated calcium (CRAC) channel orthologous to the vertebrate ORAI family of proteins; ORAI-1 activity is required for normal levels of fertility and for store-operated calcium channel (SOCC) activity in intestinal epithelial cells; co-expression of ORAI-1 and STIM-1 in HEK293 cells results in large inwardly rectifying cation currents activated by endoplasmic reticulum calcium depletion; ORAI-1 is expressed in the gonad and in the intestine; in the intestine, ORAI-1 appears to localize to the apical and basal plasma membrane; in the spermatheca, ORAI-1 expression is consistent with localization to the basal plasma membrane. | Paper_evidence | WBPaper00028994 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 21 May 2014 00:00:00 | ||||||||
Automated_description | Enables store-operated calcium channel activity. Involved in ovulation and store-operated calcium entry. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated calcium channel complex. Expressed in gonadal sheath cell; head; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Is an ortholog of human ORAI2 (ORAI calcium release-activated calcium modulator 2) and ORAI3 (ORAI calcium release-activated calcium modulator 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0080686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25896) | ||||
DOID:0111976 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25896) | ||||||
Molecular_info | Corresponding_CDS | C09F5.2a | |||||||
C09F5.2b | |||||||||
Corresponding_CDS_history | C09F5.2:wp194 | ||||||||
Corresponding_transcript | C09F5.2a.1 | ||||||||
C09F5.2a.2 | |||||||||
C09F5.2b.1 | |||||||||
Other_sequence (41) | |||||||||
Associated_feature (13) | |||||||||
Experimental_info | RNAi_result | WBRNAi00090597 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00028729 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00010525 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085731 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00001126 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00054897 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00040207 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00006596 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (9) | |||||||||
Drives_construct | WBCnstr00002229 | ||||||||
WBCnstr00004260 | |||||||||
WBCnstr00008590 | |||||||||
WBCnstr00012242 | |||||||||
WBCnstr00028687 | |||||||||
Construct_product | WBCnstr00008590 | ||||||||
WBCnstr00012242 | |||||||||
WBCnstr00028687 | |||||||||
Microarray_results (31) | |||||||||
Expression_cluster (107) | |||||||||
Interaction | WBInteraction000556188 | ||||||||
WBInteraction000556189 | |||||||||
WBInteraction000556190 | |||||||||
WBInteraction000556191 | |||||||||
Map_info | Map | III | Position | -26.3293 | Error | 0.015704 | |||
Positive | Positive_clone | C09F5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (5) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |