WormBase Tree Display for Gene: WBGene00015648
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WBGene00015648 | SMap | S_parent | Sequence | CHROMOSOME_III | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | orai-1 | Person_evidence | WBPerson1851 | |||
Sequence_name | C09F5.2 | ||||||
Molecular_name | C09F5.2a | ||||||
C09F5.2a.1 | |||||||
CE42990 | |||||||
C09F5.2b | |||||||
CE01774 | |||||||
C09F5.2a.2 | |||||||
C09F5.2b.1 | |||||||
Other_name | CELE_C09F5.2 | Accession_evidence | NDB | BX284603 | |||
Public_name | orai-1 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (3) | ||||||
Acquires_merge | WBGene00021065 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | orai | ||||||
Allele (179) | |||||||
Strain | WBStrain00002066 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (16) | |||||||
Contained_in_operon | CEOP3859 | ||||||
Ortholog (46) | |||||||
Structured_description | Concise_description | orai-1 encodes a calcium release activated calcium (CRAC) channel orthologous to the vertebrate ORAI family of proteins; ORAI-1 activity is required for normal levels of fertility and for store-operated calcium channel (SOCC) activity in intestinal epithelial cells; co-expression of ORAI-1 and STIM-1 in HEK293 cells results in large inwardly rectifying cation currents activated by endoplasmic reticulum calcium depletion; ORAI-1 is expressed in the gonad and in the intestine; in the intestine, ORAI-1 appears to localize to the apical and basal plasma membrane; in the spermatheca, ORAI-1 expression is consistent with localization to the basal plasma membrane. | Paper_evidence | WBPaper00028994 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 21 May 2014 00:00:00 | ||||||
Automated_description | Enables store-operated calcium channel activity. Involved in ovulation and store-operated calcium entry. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated calcium channel complex. Expressed in gonadal sheath cell; head; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Is an ortholog of human ORAI2 (ORAI calcium release-activated calcium modulator 2) and ORAI3 (ORAI calcium release-activated calcium modulator 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0080686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25896) | ||
DOID:0111976 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25896) | ||||
Molecular_info | Corresponding_CDS | C09F5.2a | |||||
C09F5.2b | |||||||
Corresponding_CDS_history | C09F5.2:wp194 | ||||||
Corresponding_transcript | C09F5.2a.1 | ||||||
C09F5.2a.2 | |||||||
C09F5.2b.1 | |||||||
Other_sequence (41) | |||||||
Associated_feature (13) | |||||||
Experimental_info (7) | |||||||
Map_info | Map | III | Position | -26.3293 | Error | 0.015704 | |
Positive | Positive_clone | C09F5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00028994 | ||||||
WBPaper00030263 | |||||||
WBPaper00038491 | |||||||
WBPaper00047380 | |||||||
WBPaper00055090 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |