WormBase Tree Display for Gene: WBGene00015135
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WBGene00015135 | SMap | S_parent | Sequence | B0304 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cyp | ||||||
Allele (55) | |||||||
Strain | WBStrain00035808 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (15) | |||||||
Ortholog (57) | |||||||
Paralog (44) | |||||||
Structured_description | Concise_description | cyp-23A1 encodes a cytochrome P450 homologous to the human gene CYP7B1, which when mutated leads to giant cell hepatitis (OMIM:231100); as a cytochrome P450, CYP-23A1 is predicted to function as a membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyzes the oxidative metabolism of a variety of exogenous compounds and endogenous substrates. | Paper_evidence | WBPaper00004637 | |||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 20 Nov 2008 00:00:00 | ||||||
Automated_description | Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Is an ortholog of human CYP2C8 (cytochrome P450 family 2 subfamily C member 8). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2622) | ||
DOID:1073 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2622) | ||||
Molecular_info | Corresponding_CDS | B0304.3 | |||||
Corresponding_transcript | B0304.3.1 | ||||||
Other_sequence (11) | |||||||
Associated_feature (15) | |||||||
Experimental_info | RNAi_result | WBRNAi00103146 | Inferred_automatically | RNAi_primary | |||
WBRNAi00038912 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00092638 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00078391 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00009688 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1028987 | ||||||
Expr1036472 | |||||||
Expr1143092 | |||||||
Expr2010695 | |||||||
Expr2028934 | |||||||
Drives_construct | WBCnstr00029059 | ||||||
Construct_product | WBCnstr00029059 | ||||||
Microarray_results (19) | |||||||
Expression_cluster (131) | |||||||
Interaction | WBInteraction000050741 | ||||||
WBInteraction000557101 | |||||||
Map_info | Map | II | Position | -4.29115 | Error | 0.046 | |
Positive | Positive_clone | B0304 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5366 | |||||
Pseudo_map_position | |||||||
Reference (4) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |