WormBase Tree Display for Gene: WBGene00014202
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WBGene00014202 | SMap | S_parent | Sequence | ZK1058 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | mmcm-1 | Person_evidence | WBPerson4388 | |||||
WBPerson4387 | |||||||||
Sequence_name | ZK1058.1 | ||||||||
Molecular_name | ZK1058.1 | ||||||||
ZK1058.1.1 | |||||||||
CE30404 | |||||||||
Other_name | CELE_ZK1058.1 | Accession_evidence | NDB | BX284603 | |||||
Public_name | mmcm-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 16 Jan 2006 17:57:11 | WBPerson2970 | Name_change | CGC_name | mmcm-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mmcm | ||||||||
Allele (60) | |||||||||
Strain | WBStrain00032132 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (23) | |||||||||
Contained_in_operon | CEOP3864 | ||||||||
Ortholog (36) | |||||||||
Paralog | WBGene00020169 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
Structured_description | Concise_description | mmcm-1 encodes an ortholog of human methylmalonyl-CoA mutase (MUT); MMCM-1 enzyme, in vitro, kinetically resembles its human ortholog; mmcm-1 deletion mutants incorporate abnormally low levels of 1-[(14)C]-propionate into proteins; mmcm-1(RNAi) and mmcm-1 deletion mutant animals excrete abnormally high levels of methylmalonic acid into their culture medium when challenged with propionic acid; mmcm-1, in a lentiviral transgene, can partially rescue the mutant phenotype of human mut(o) fibroblasts; these data are consistent with the hypothesis that MMCM-1 participates in the conversion of propionyl-CoA to succinyl-CoA. | Paper_evidence | WBPaper00004588 | |||||
WBPaper00004637 | |||||||||
WBPaper00027754 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 02 Oct 2006 00:00:00 | ||||||||
Automated_description | Enables methylmalonyl-CoA mutase activity. Involved in amino acid metabolic process and fatty acid metabolic process. Located in mitochondrion. Used to study methylmalonic acidemia. Human ortholog(s) of this gene implicated in methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency. Is an ortholog of human MMUT (methylmalonyl-CoA mutase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info (3) | |||||||||
Models_disease_asserted | WBDOannot00000284 | ||||||||
Molecular_info | Corresponding_CDS | ZK1058.1 | |||||||
Corresponding_transcript | ZK1058.1.1 | ||||||||
Other_sequence (134) | |||||||||
Associated_feature | WBsf666451 | ||||||||
WBsf666715 | |||||||||
WBsf666716 | |||||||||
WBsf226427 | |||||||||
WBsf226428 | |||||||||
WBsf226429 | |||||||||
Experimental_info | RNAi_result | WBRNAi00059082 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00078223 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00006035 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038132 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00007126 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00059081 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00106988 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr1017573 | ||||||||
Expr1036359 | |||||||||
Expr1162512 | |||||||||
Expr2013626 | |||||||||
Expr2031860 | |||||||||
Drives_construct | WBCnstr00029229 | ||||||||
Construct_product | WBCnstr00029229 | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (134) | |||||||||
Interaction (30) | |||||||||
Map_info | Map | III | Position | -4.23496 | |||||
Positive | Positive_clone | ZK1058 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 5662 | |||||||
4791 | |||||||||
Pseudo_map_position | |||||||||
Reference (15) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |