WormBase Tree Display for Gene: WBGene00014153
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| WBGene00014153 | SMap | S_parent | Sequence | ZK930 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | vab-23 | Paper_evidence | WBPaper00035263 | |||||
| Person_evidence | WBPerson232 | ||||||||
| Sequence_name | ZK930.3 | ||||||||
| Molecular_name | ZK930.3a | ||||||||
| ZK930.3a.1 | |||||||||
| CE37948 | |||||||||
| ZK930.3b | |||||||||
| CE37306 | |||||||||
| ZK930.3b.1 | |||||||||
| Other_name | CELE_ZK930.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | vab-23 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 19 Oct 2009 17:02:44 | WBPerson9133 | Name_change | CGC_name | vab-23 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vab | ||||||||
| Allele (88) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00079271 | ||||||||
| 00079272 | |||||||||
| 00079273 | |||||||||
| 00079274 | |||||||||
| 00079275 | |||||||||
| 00079276 | |||||||||
| 00079277 | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00014152 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | vab-23 encodes a novel 253 amino acid coiled-coil containing a C-terminal C4H2 zinc finger domain; VAB-23 is a conserved protein and has a strong homology to human hepatocellular carcinoma antigen (HCA127) (OMIM: 610334); vab-23 is required in ventral neuroblasts for ventral closure and elongation of the embryo, specifically to regulate proper cell contacts between contralateral pairs of ventral epidermal cells; vab-23 is also required for vulval cell morphogenesis; in regulating vulval development, vab-23 acts downstream of the EGFR/RAS/MAPK pathway and the CEH-20 and LIN-39 transcription factors, the latter of which binds vab-23 regulatory sequence; VAB-23, in turn, regulates the expression of the SMP-1 semaphorin, the EFF-1 fusogen, the EGL-26 acyltransferase, and LIN-3/EGF in vulval cells, binding SMP-1 and EGL-26 regulatory sequence in vivo; the highly conserved C-terminal zinc finger domain of VAB-23 is necessary for VAB-23 function; VAB-23::GFP is expressed in the nuclei at the onset of epidermal morphogenesis, predominantly on the ventral posterior of the embryo, ventral neuroblasts, and two posterior ventral epidermal cells; within nuclei, VAB-23::GFP appears to localize to nuclear speckles that correspond to regions of lower DNA content. | Paper_evidence | WBPaper00035263 | |||||
| WBPaper00040292 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 06 Jul 2011 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including embryonic body morphogenesis; epidermis morphogenesis; and vulval development. Located in nuclear speck. Expressed in several structures, including hermaphrodite somatic gonadal cell; ventral uterine precursor; vulval cell; vulval muscle; and vulval precursor cell. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Is an ortholog of human ZC4H2 (zinc finger C4H2-type containing). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060815 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:24931) | ||||
| Molecular_info | Corresponding_CDS | ZK930.3a | |||||||
| ZK930.3b | |||||||||
| Corresponding_CDS_history | ZK930.3:wp57 | ||||||||
| ZK930.3:wp125 | |||||||||
| ZK930.3a:wp137 | |||||||||
| Corresponding_transcript | ZK930.3a.1 | ||||||||
| ZK930.3b.1 | |||||||||
| Other_sequence (16) | |||||||||
| Associated_feature (14) | |||||||||
| Transcription_factor | WBTranscriptionFactor000757 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00071790 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00071230 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081766 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059833 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00087182 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027119 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009505 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8814 | ||||||||
| Expr9649 | |||||||||
| Expr1013628 | |||||||||
| Expr1036341 | |||||||||
| Expr1163261 | |||||||||
| Expr2017949 | |||||||||
| Expr2036085 | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product (15) | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (162) | |||||||||
| Interaction (50) | |||||||||
| Map_info | Map | II | Position | 4.13547 | Error | 0.000657 | |||
| Positive | Positive_clone | ZK930 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00035263 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040292 | |||||||||
| WBPaper00044221 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
