WormBase Tree Display for Gene: WBGene00013557
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| WBGene00013557 | SMap | S_parent | Sequence | Y75B8A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | Sequence_name | Y75B8A.24 | |||||||
| Molecular_name | Y75B8A.24 | ||||||||
| Y75B8A.24.1 | |||||||||
| CE44318 | |||||||||
| Y75B8A.24.2 | |||||||||
| Other_name | CELE_Y75B8A.24 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | Y75B8A.24 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Allele (628) | |||||||||
| Strain | WBStrain00037409 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00103144 | ||||||||
| 00103145 | |||||||||
| 00103146 | |||||||||
| 00103147 | |||||||||
| 00103148 | |||||||||
| 00103149 | |||||||||
| 00103150 | |||||||||
| 00103151 | |||||||||
| 00103152 | |||||||||
| 00120389 | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00000090 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006932 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009552 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018076 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Automated_description | Predicted to enable 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Predicted to be located in cytoplasm and plasma membrane. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 84. Is an ortholog of human PI4KA (phosphatidylinositol 4-kinase alpha). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:0112347 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8983) | |||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including PI4KA (phosphatidylinositol 4-kinase, catalytic, alpha), which catalyses the first step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate; C. elegans Y75B8A.24 encodes a putative ortholog of human PRODH and is an essential gene, knock-outs of the gene are embryonic lethal, knock-down phenotypes include slow growth and sterility. | Homo sapiens | Paper_evidence | WBPaper00047004 | |||||
| Accession_evidence | OMIM | 611867 | |||||||
| 616531 | |||||||||
| 600286 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000375 | ||||||||
| Molecular_info | Corresponding_CDS | Y75B8A.24 | |||||||
| Corresponding_CDS_history | Y75B8A.24:wp209 | ||||||||
| Corresponding_transcript | Y75B8A.24.1 | ||||||||
| Y75B8A.24.2 | |||||||||
| Other_sequence (59) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00006902 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00002097 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061392 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058454 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1018127 | ||||||||
| Expr1036058 | |||||||||
| Expr1161870 | |||||||||
| Expr2008414 | |||||||||
| Expr2026655 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (94) | |||||||||
| Interaction | WBInteraction000037409 | ||||||||
| WBInteraction000046472 | |||||||||
| WBInteraction000170121 | |||||||||
| WBInteraction000173401 | |||||||||
| WBInteraction000173972 | |||||||||
| WBInteraction000174337 | |||||||||
| WBInteraction000543487 | |||||||||
| Map_info | Positive | Positive_clone | Y75B8A | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Interpolated_map_position | III | 16.2739 | |||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00040857 | |||||||||
| WBPaper00055090 | |||||||||
| Method | Gene |
