WormBase Tree Display for Gene: WBGene00012550
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WBGene00012550 | SMap | S_parent | Sequence | Y37D8A | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | spcs | |||||
Allele (17) | ||||||
Strain | WBStrain00037795 | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (11) | ||||||
Ortholog (35) | ||||||
Structured_description | Automated_description | Involved in IRE1-mediated unfolded protein response. Located in sarcoplasmic reticulum. Used to study Parkinson's disease. Is an ortholog of human SPCS2 (signal peptidase complex subunit 2). | Paper_evidence | WBPaper00065943 | ||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00041253 | |
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 20 Nov 2013 00:00:00 | |||||
Disease_relevance | In elegans, hpo-21, orthologous to human SPCS1, is involved with several other hpo genes in the protective response against pore-forming toxins; hpo-21 has been shown to have a protective effect in an elegans model for alpha-synuclein (alpha-syn) toxicity (implicated in Parkinson''s disease, and other alpha-synucleinopathies); this model consists of overexpression of human alpha-syn fused to green fluorescent protein (GFP) in body wall muscle cells, resulting in age-dependent alpha-syn misfolding in the cytoplasm; co-expression of a chaperone, TOR-2, in this system reduces alpha-syn-GFP misfolding, providing a genetic background in which the enhancement of alpha-syn misfolding is easily visualized; hpo-21 was identified as a interactor of catp-6/ATP13A2; deficiency of catp-6/ATP13A2 and its interactors, including hpo-21, exacerbates alpha-syn misfolding in the above elegans model. | Homo sapiens | Paper_evidence | WBPaper00038231 | ||
WBPaper00041253 | ||||||
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 20 Nov 2013 00:00:00 | |||||
Models_disease_in_annotation | WBDOannot00000252 | |||||
Molecular_info | Corresponding_CDS | Y37D8A.10 | ||||
Corresponding_transcript | Y37D8A.10.1 | |||||
Other_sequence (49) | ||||||
Associated_feature | WBsf645677 | |||||
WBsf225936 | ||||||
WBsf225937 | ||||||
Experimental_info | RNAi_result (16) | |||||
Expr_pattern | Expr9419 | |||||
Expr1014401 | ||||||
Expr1035553 | ||||||
Expr1159394 | ||||||
Expr2012563 | ||||||
Expr2030800 | ||||||
Drives_construct | WBCnstr00029908 | |||||
Construct_product | WBCnstr00013984 | |||||
WBCnstr00029908 | ||||||
Microarray_results (20) | ||||||
Expression_cluster (90) | ||||||
Interaction (55) | ||||||
Map_info (3) | ||||||
Reference | WBPaper00024200 | |||||
WBPaper00035925 | ||||||
WBPaper00038444 | ||||||
WBPaper00038491 | ||||||
WBPaper00055090 | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |