WormBase Tree Display for Gene: WBGene00012550
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WBGene00012550 | SMap | S_parent | Sequence | Y37D8A | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||||
Name | CGC_name | spcs-2 | |||||||
Sequence_name | Y37D8A.10 | ||||||||
Molecular_name | Y37D8A.10 | ||||||||
Y37D8A.10.1 | |||||||||
CE20214 | |||||||||
Other_name | hpo-21 | ||||||||
CELE_Y37D8A.10 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | spcs-2 | ||||||||
DB_info | Database | AceView | gene | 3N965 | |||||
WormQTL | gene | WBGene00012550 | |||||||
WormFlux | gene | WBGene00012550 | |||||||
NDB | locus_tag | CELE_Y37D8A.10 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00012550|UniProtKB=Q9XWW1 | |||||||
family | PTHR13085 | ||||||||
NCBI | gene | 176703 | |||||||
RefSeq | protein | NM_067275.8 | |||||||
SwissProt | UniProtAcc | Q9XWW1 | |||||||
TREEFAM | TREEFAM_ID | TF314545 | |||||||
UniProt_GCRP | UniProtAcc | Q9XWW1 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 26 Apr 2011 13:31:47 | WBPerson2970 | Name_change | CGC_name | hpo-21 | ||||
3 | 12 Nov 2018 16:28:49 | WBPerson1983 | Name_change | CGC_name | spcs-2 | ||||
Other_name | hpo-21 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | spcs | ||||||||
Allele (17) | |||||||||
Strain | WBStrain00037795 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (11) | |||||||||
Ortholog (35) | |||||||||
Structured_description | Automated_description | Involved in IRE1-mediated unfolded protein response. Located in sarcoplasmic reticulum. Used to study Parkinson's disease. Is an ortholog of human SPCS2 (signal peptidase complex subunit 2). | Paper_evidence | WBPaper00065943 | |||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00041253 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 20 Nov 2013 00:00:00 | ||||||||
Disease_relevance | In elegans, hpo-21, orthologous to human SPCS1, is involved with several other hpo genes in the protective response against pore-forming toxins; hpo-21 has been shown to have a protective effect in an elegans model for alpha-synuclein (alpha-syn) toxicity (implicated in Parkinson''s disease, and other alpha-synucleinopathies); this model consists of overexpression of human alpha-syn fused to green fluorescent protein (GFP) in body wall muscle cells, resulting in age-dependent alpha-syn misfolding in the cytoplasm; co-expression of a chaperone, TOR-2, in this system reduces alpha-syn-GFP misfolding, providing a genetic background in which the enhancement of alpha-syn misfolding is easily visualized; hpo-21 was identified as a interactor of catp-6/ATP13A2; deficiency of catp-6/ATP13A2 and its interactors, including hpo-21, exacerbates alpha-syn misfolding in the above elegans model. | Homo sapiens | Paper_evidence | WBPaper00038231 | |||||
WBPaper00041253 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 20 Nov 2013 00:00:00 | ||||||||
Models_disease_in_annotation | WBDOannot00000252 | ||||||||
Molecular_info | Corresponding_CDS | Y37D8A.10 | |||||||
Corresponding_transcript | Y37D8A.10.1 | ||||||||
Other_sequence (49) | |||||||||
Associated_feature | WBsf645677 | ||||||||
WBsf225936 | |||||||||
WBsf225937 | |||||||||
Experimental_info | RNAi_result (16) | ||||||||
Expr_pattern (6) | |||||||||
Drives_construct | WBCnstr00029908 | ||||||||
Construct_product | WBCnstr00013984 | ||||||||
WBCnstr00029908 | |||||||||
Microarray_results (20) | |||||||||
Expression_cluster (90) | |||||||||
Interaction (55) | |||||||||
Map_info (3) | |||||||||
Reference | WBPaper00024200 | ||||||||
WBPaper00035925 | |||||||||
WBPaper00038444 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00055090 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |