WormBase Tree Display for Gene: WBGene00011821

WBGene00011821 SMap: S_parent: Sequence: T18D3
  Identity: Version: 2
    Name: CGC_name: cdf-2 Paper_evidence: WBPaper00033166
          Person_evidence: WBPerson341
      Sequence_name: T18D3.3
      Molecular_name: T18D3.3a
        T18D3.3a.1
        CE41338
        T18D3.3b
        CE50554
        T18D3.3b.1
      Other_name: CELE_T18D3.3 Accession_evidence: NDB BX284606
      Public_name: cdf-2
    DB_info: Database: AceView gene XN84
        WormQTL gene WBGene00011821
        WormFlux gene WBGene00011821
        NDB locus_tag CELE_T18D3.3
        Panther gene CAEEL|EnsemblGenome=WBGene00011821|UniProtKB=Q22541
          family PTHR11562
        NCBI gene 188574
        RefSeq protein NM_001313452.1
            NM_077690.4
        TrEMBL UniProtAcc A0A0K3AVP5
            Q22541
        UniProt_GCRP UniProtAcc Q22541
        OMIM gene 611145
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 27 Jul 2009 15:03:57 WBPerson9133 Name_change: CGC_name: cdf-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cdf
    Allele (45)
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (39)
    Paralog: WBGene00012712 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000393 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006590 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00010644 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013668 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018948 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019803 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019841 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00044481 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: cdf-2 encodes a protein similar to members of the cation diffusion facilitator (CDF) family of transmembrane proteins and is most similar to vertebrate ZnT-2; two other elegans CDF proteins, cdf-1 and sur-7 have also been identified; CDF proteins regulate the transport of heavy metal ions like zinc; cdf-2 responds to dietary zinc as cdf-2 transcript levels can be correlated with dietary zinc concentrations; cdf-2 promotes the accumulation of zinc; the cdf-2 protein is expressed in intestinal cells and localizes to cytosolic vesicles. Paper_evidence: WBPaper00035924
          Curator_confirmed: WBPerson324
          Date_last_updated: 16 Nov 2010 00:00:00
      Automated_description: Predicted to enable zinc ion transmembrane transporter activity. Involved in cellular response to zinc ion and zinc ion transmembrane transport. Located in gut granule membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human SLC30A8 (solute carrier family 30 member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20303)
  Molecular_info: Corresponding_CDS: T18D3.3a
      T18D3.3b
    Corresponding_CDS_history: T18D3.3:wp178
    Corresponding_transcript: T18D3.3a.1
      T18D3.3b.1
    Other_sequence (53)
    Associated_feature: WBsf654479
      WBsf654480
      WBsf671115
      WBsf982249
      WBsf982359
      WBsf982360
      WBsf1007306
      WBsf1007307
      WBsf238065
      WBsf238066
  Experimental_info: RNAi_result: WBRNAi00053467 Inferred_automatically: RNAi_primary
      WBRNAi00070073 Inferred_automatically: RNAi_primary
      WBRNAi00107998 Inferred_automatically: RNAi_primary
      WBRNAi00108003 Inferred_automatically: RNAi_primary
      WBRNAi00114325 Inferred_automatically: RNAi_primary
      WBRNAi00018801 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8721
      Expr11664
      Expr1012086
      Expr1035208
      Expr1157031
      Expr2009796
      Expr2028036
    Drives_construct: WBCnstr00005627
      WBCnstr00005628
      WBCnstr00005629
      WBCnstr00013851
      WBCnstr00030358
    Construct_product: WBCnstr00005627
      WBCnstr00005628
      WBCnstr00005629
      WBCnstr00013851
      WBCnstr00020147
      WBCnstr00030358
    Microarray_results (19)
    Expression_cluster (179)
    Interaction (24)
    WBProcess: WBbiopr:00000096
  Map_info: Map: X Position: 7.10541 Error: 0.001301
    Positive: Positive_clone: T18D3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (21)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene