WormBase Tree Display for Gene: WBGene00011671
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| WBGene00011671 | SMap | S_parent | Sequence | T10B9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | cyp-13A4 | |||||||
| Sequence_name | T10B9.1 | ||||||||
| Molecular_name | T10B9.1 | ||||||||
| T10B9.1.1 | |||||||||
| CE01654 | |||||||||
| Other_name | dod-1 | CGC_data_submission | |||||||
| ccp-13A4 | CGC_data_submission | ||||||||
| CELE_T10B9.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | cyp-13A4 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 25 Aug 2004 11:18:28 | WBPerson1971 | Name_change | CGC_name | ccp-13A4 | ||||
| Other_name | dod-1 | ||||||||
| 3 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | ccp-13A4 -> cyp-13A4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyp | ||||||||
| Allele (36) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00079944 | ||||||||
| 00079945 | |||||||||
| 00079946 | |||||||||
| 00118895 | |||||||||
| 00118896 | |||||||||
| 00118897 | |||||||||
| 00118898 | |||||||||
| Ortholog (67) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | cyp-13A4 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates; loss of cyp-13A4 activity in large-scale RNAi screens in wild-type and various mutant backgrounds results in uncoordinated locomotion, reduced and/or slow growth, alterations in adult lifespan, and cadmium hypersensitivity. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00005976 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00030811 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Nov 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; familial Mediterranean fever; and leukemia (multiple). Is an ortholog of several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A5 (cytochrome P450 family 3 subfamily A member 5); and CYP3A7 (cytochrome P450 family 3 subfamily A member 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:8552 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||
| DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11609) | ||||||
| DOID:2987 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2637) | ||||||
| DOID:9952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||||
| DOID:0112251 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11609) | ||||||
| DOID:0080630 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2637) | ||||||
| Molecular_info | Corresponding_CDS | T10B9.1 | |||||||
| Corresponding_transcript | T10B9.1.1 | ||||||||
| Other_sequence | PSC01041_1 | ||||||||
| CV199467.1 | |||||||||
| PVC00466_1 | |||||||||
| GW410004.1 | |||||||||
| CJC10203_1 | |||||||||
| Associated_feature | WBsf019145 | ||||||||
| WBsf019146 | |||||||||
| WBsf019147 | |||||||||
| WBsf989151 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr1028998 | ||||||||
| Expr1156613 | |||||||||
| Expr2010684 | |||||||||
| Drives_construct | WBCnstr00030482 | ||||||||
| Construct_product | WBCnstr00030482 | ||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (135) | |||||||||
| Interaction (30) | |||||||||
| Map_info | Map | II | Position | 1.71585 | Error | 0.000234 | |||
| Positive | Positive_clone | T10B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005976 | ||||||||
| WBPaper00028352 | |||||||||
| WBPaper00030811 | |||||||||
| WBPaper00035663 | |||||||||
| WBPaper00037579 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042257 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064598 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
