WormBase Tree Display for Gene: WBGene00009218

WBGene00009218 SMap: S_parent: Sequence: F28D1
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: acs
    Allele (88)
    Strain (2)
    RNASeq_FPKM (74)
    GO_annotation: 00066220
      00066221
      00066222
      00066223
      00066224
      00066225
      00066226
      00066227
    Ortholog (42)
    Paralog (17)
    Structured_description: Concise_description: acs-20 encodes a protein homologous to the mammalian FATP1 and FATP4 fatty acid transport proteins (FATP)/very long chain fatty acid acyl-CoA synthetases; acs-20 activity is required for proper cuticle development, specifically formation of a cuticle surface barrier that prevents penetration of small molecules; acs-20 may affect cuticle development via its role in incorporation of very long chain fatty acids, but not other fatty acids, into sphingomyelin; acs-20; acs-22 doubly mutant animals have moresevere cuticle barrier defects than acs-20 single mutants, suggesting that the two genes function redundantly; acs-20 defects can be rescued by human Fatp4; an ACS-20::GFP fusion protein is expressed in the hyp7 and seam hypodermis, as well as the vulval and anal muscles; in hypodermal cells, ACS-20 localizes in a reticular pattern suggestive of localization to the endoplasmic reticulum. Paper_evidence: WBPaper00035868
          Curator_confirmed: WBPerson1843
          Date_last_updated: 03 Feb 2010 00:00:00
      Automated_description: Predicted to enable long-chain fatty acid transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in triglyceride homeostasis. Located in intracellular membrane-bounded organelle. Expressed in anal depressor muscle; anal sphincter muscle; head; hyp7 syncytium; and seam cell. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10998)
  Molecular_info: Corresponding_CDS: F28D1.9
    Corresponding_CDS_history: F28D1.9:wp154
    Corresponding_transcript: F28D1.9.1
    Other_sequence (33)
    Associated_feature (13)
  Experimental_info: RNAi_result (23)
    Expr_pattern: Chronogram984
      Expr5903
      Expr8893
      Expr8895
      Expr1026843
      Expr1034021
      Expr1149741
      Expr2009210
      Expr2027447
    Drives_construct: WBCnstr00002507
      WBCnstr00007265
      WBCnstr00013587
      WBCnstr00013589
      WBCnstr00022750
      WBCnstr00022752
      WBCnstr00032361
    Construct_product: WBCnstr00007265
      WBCnstr00013589
      WBCnstr00022752
      WBCnstr00022754
      WBCnstr00032361
    Microarray_results (17)
    Expression_cluster (233)
    Interaction (173)
  Map_info: Map: IV Position: 5.90843 Error: 0.002883
    Positive: Positive_clone: F28D1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene