WormBase Tree Display for Gene: WBGene00007732
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WBGene00007732 | SMap | S_parent | Sequence | C25G4 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 5 | |||||
Name | CGC_name | spe-44 | Paper_evidence | WBPaper00041071 | |||
Person_evidence | WBPerson725 | ||||||
Sequence_name | C25G4.4 | ||||||
Molecular_name | C25G4.4 | ||||||
C25G4.4.1 | |||||||
CE05305 | |||||||
Other_name | gmeb-4 | Person_evidence | WBPerson260 | ||||
tag-347 | |||||||
CELE_C25G4.4 | Accession_evidence | NDB | BX284604 | ||||
Public_name | spe-44 | ||||||
DB_info | Database | AceView | gene | 4N218 | |||
WormQTL | gene | WBGene00007732 | |||||
WormFlux | gene | WBGene00007732 | |||||
NDB | locus_tag | CELE_C25G4.4 | |||||
Panther | gene | CAEEL|WormBase=WBGene00007732|UniProtKB=Q18171 | |||||
family | PTHR10417 | ||||||
NCBI | gene | 182915 | |||||
RefSeq | protein | NM_069978.6 | |||||
SwissProt | UniProtAcc | Q18171 | |||||
TREEFAM | TREEFAM_ID | TF317090 | |||||
UniProt_GCRP | UniProtAcc | Q18171 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (5) | ||||||
Acquires_merge | WBGene00045485 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | spe | ||||||
Allele (35) | |||||||
Strain | WBStrain00033487 | ||||||
WBStrain00031119 | |||||||
WBStrain00031120 | |||||||
WBStrain00033484 | |||||||
WBStrain00034724 | |||||||
WBStrain00036311 | |||||||
WBStrain00051868 | |||||||
WBStrain00051870 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Contained_in_operon | CEOP4516 | ||||||
Ortholog (36) | |||||||
Paralog | WBGene00015285 | Caenorhabditis elegans | From_analysis (3) | ||||
WBGene00008092 | Caenorhabditis elegans | From_analysis (3) | |||||
WBGene00010010 | Caenorhabditis elegans | From_analysis (3) | |||||
Structured_description | Concise_description | spe-44 encodes a SAND (for Sp100, Aire, NucP41/75, DEAF-1) domain-containing protein that is one of four C. elegans proteins related to the mammalian glucocorticoid modulatory element-binding proteins GMEB-1 and GMEB-2; SPE-44 is one of the earliest markers of sperm fate and its activity is essential for regulation of sperm-specific genes during spermatogenesis; microarray analyses indicate the SPE-44 is required for expression of a number of sperm-specific genes, including those that encode the Major Sperm Proteins (MSPs), members of the small sperm-specific protein family, other SPE proteins such as SPE-7, and the ELT-1 GATA transcription factor; when expressed in yeast, SPE-44 can directly activate transcription of a lacZ reporter gene containing the spe-7 promoter region; spe-44 expression coincides with commitment to the sperm fate at the L3 larval stage, and persists throughout spermatogenesis in hermaphrodites and males; SPE-44 protein is first detected in the early meiotic zone, co-localizes with meiotic autosomes in the pachytene region, and becomes non-chromosomal before disappearing in karyosome stage nuclei; spe-44 expression is controlled by terminal regulators of the germline sex determination pathway, such as fem-1, fem-3, and fog-1. | Paper_evidence | WBPaper00041071 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 16 Apr 2013 00:00:00 | ||||||
Automated_description | Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II and spermatogenesis. Located in autosome. Expressed in germ line; sperm; and in male. Is an ortholog of human GMEB1 (glucocorticoid modulatory element binding protein 1) and GMEB2 (glucocorticoid modulatory element binding protein 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C25G4.4 | |||||
Corresponding_transcript | C25G4.4.1 | ||||||
Associated_feature | WBsf668432 | ||||||
WBsf668433 | |||||||
WBsf978427 | |||||||
WBsf231024 | |||||||
Transcription_factor | WBTranscriptionFactor000616 | ||||||
Experimental_info | RNAi_result | WBRNAi00041213 | Inferred_automatically | RNAi_primary | |||
WBRNAi00076159 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00011180 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00029204 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr10041 | ||||||
Expr11705 | |||||||
Expr11706 | |||||||
Expr1014891 | |||||||
Expr1033347 | |||||||
Expr1145249 | |||||||
Expr1200179 | |||||||
Expr2016042 | |||||||
Expr2034277 | |||||||
Drives_construct | WBCnstr00037868 | ||||||
Construct_product | WBCnstr00037868 | ||||||
Regulate_expr_cluster | WBPaper00041071:spe-44_downregulated | ||||||
WBPaper00041071:spe-44_upregulated | |||||||
WBPaper00064502:nhr-23(kry61);spe-44(fx110)_downregulated | |||||||
WBPaper00064502:nhr-23(kry61);spe-44(fx110)_upregulated | |||||||
WBPaper00064502:spe-44(fx110)_downregulated | |||||||
WBPaper00064502:spe-44(fx110)_upregulated | |||||||
Antibody | WBAntibody00002339 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (129) | |||||||
Interaction (80) | |||||||
Map_info | Map | IV | Position | 5.96572 | Error | 0.006805 | |
Positive | Positive_clone | C25G4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5281 | |||||
Pseudo_map_position | |||||||
Reference (15) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |