WormBase Tree Display for Gene: WBGene00007626
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| WBGene00007626 | SMap | S_parent | Sequence | C16C10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | rnf-121 | Person_evidence | WBPerson2094 | |||||
| Sequence_name | C16C10.5 | ||||||||
| Molecular_name | C16C10.5 | ||||||||
| C16C10.5.1 | |||||||||
| CE49432 | |||||||||
| Other_name | CELE_C16C10.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | rnf-121 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 05 Jan 2007 17:15:03 | WBPerson1847 | Name_change | CGC_name | rnf-121 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rnf | ||||||||
| Allele (27) | |||||||||
| Strain | WBStrain00031664 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Contained_in_operon | CEOP3156 | ||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | rnf-121 encodes a RING finger E3 ubiquitin ligase; RNF-121 appears to function in the endoplasmic reticulum-associated degradation (ERAD) pathway downstream of PEK-1; RNF-121 exhibits E3 ubiquitin-protein ligase activity in vitro and in vivo regulates levels of the PAT-3 beta integrin subunit which is an RNF-121 substrate; RNF-121 may thus regulate cell adhesion through control of PAT-3 levels, consistent with gonad and germline defects seen upon RNF-121 overexpression; RNF-121 is required for distal tip cell migration (DTC) and genetic interactions suggest that RNF-121 functions at least partially in parallel with the coiled-coil domain protein CCDC-55 and the E3 ubiquitin ligase RNF-5 to regulate DTC migration; RNF-121 is expressed in the hypodermis, including the seam cells, the vulva, uterus, spermatheca, sheath cells, and distal tip cells; RNF-121 localizes to membranes of the endoplasmic reticulum, the sarcoplasmic reticulum, and the Golgi. | Paper_evidence | WBPaper00036076 | |||||
| WBPaper00040713 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Nov 2013 00:00:00 | ||||||||
| Automated_description | Enables ubiquitin protein ligase activity. Involved in PERK-mediated unfolded protein response; inductive cell migration; and ubiquitin-dependent ERAD pathway. Located in Golgi membrane and sarcoplasmic reticulum membrane. Expressed in body wall musculature; gonad; hypodermis; and vulva. Is an ortholog of human RNF121 (ring finger protein 121) and RNF175 (ring finger protein 175). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C16C10.5 | |||||||
| Corresponding_CDS_history | C16C10.5:wp240 | ||||||||
| Corresponding_transcript | C16C10.5.1 | ||||||||
| Other_sequence (41) | |||||||||
| Associated_feature | WBsf650957 | ||||||||
| WBsf666453 | |||||||||
| WBsf666748 | |||||||||
| WBsf226479 | |||||||||
| WBsf226480 | |||||||||
| WBsf226481 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr9016 | ||||||||
| Expr1020021 | |||||||||
| Expr1033292 | |||||||||
| Expr1144727 | |||||||||
| Expr2015382 | |||||||||
| Expr2033616 | |||||||||
| Drives_construct | WBCnstr00006033 | ||||||||
| WBCnstr00007192 | |||||||||
| WBCnstr00033597 | |||||||||
| Construct_product | WBCnstr00006033 | ||||||||
| WBCnstr00007192 | |||||||||
| WBCnstr00007193 | |||||||||
| WBCnstr00007194 | |||||||||
| WBCnstr00033597 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (71) | |||||||||
| Interaction (12) | |||||||||
| WBProcess | WBbiopr:00000076 | ||||||||
| Map_info | Map | III | Position | -3.72075 | Error | 0.002855 | |||
| Positive | Positive_clone | C16C10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027315 | ||||||||
| WBPaper00036076 | |||||||||
| WBPaper00036306 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040713 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00059773 | |||||||||
| WBPaper00060756 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
