WormBase Tree Display for Gene: WBGene00007529
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| WBGene00007529 | SMap | S_parent | Sequence | C11H1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mgrn-1 | Person_evidence | WBPerson7514 | |||||
| Sequence_name | C11H1.3 | ||||||||
| Molecular_name | C11H1.3 | ||||||||
| C11H1.3.1 | |||||||||
| CE05262 | |||||||||
| Other_name | CELE_C11H1.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mgrn-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 02 Mar 2022 23:57:00 | WBPerson51134 | Name_change | CGC_name | mgrn-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mgrn | ||||||||
| Allele (70) | |||||||||
| Strain | WBStrain00002779 | ||||||||
| WBStrain00055358 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Contained_in_operon | CEOPX134 | ||||||||
| Ortholog (41) | |||||||||
| Structured_description | Concise_description | C11H1.3 encodes a ring finger-domain containing protein with similarity to the mammlian MGRN1 (Mahogunin 1) and RNF157 proteins; by homology with MGRN1, C11H1.3 is predicted to function as a ubiquitin ligase that regulates protein catabolism via the proteasome; in C. elegans, C11H1.3 activity is required for normal localization and expression of the LET-23 EGF receptor in vulval cell lineages and for normal vulval development; C11H1.3 is also required for normal GABAergic neurotransmission; C11H1.3 is expressed in the nervous system, the pharynx, and in the vulval precursors cells. | Paper_evidence | WBPaper00045219 | |||||
| WBPaper00031872 | |||||||||
| WBPaper00028592 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 21 Aug 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of vulval development and protein localization to basolateral plasma membrane. Located in cytoplasmic vesicle. Expressed in vulval precursor cell. Is an ortholog of human MGRN1 (mahogunin ring finger 1) and RNF157 (ring finger protein 157). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C11H1.3 | |||||||
| Corresponding_transcript | C11H1.3.1 | ||||||||
| Other_sequence (35) | |||||||||
| Associated_feature | WBsf979009 | ||||||||
| WBsf1007874 | |||||||||
| WBsf1024377 | |||||||||
| WBsf238228 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram1606 | ||||||||
| Expr4305 | |||||||||
| Expr5243 | |||||||||
| Expr11778 | |||||||||
| Expr1018623 | |||||||||
| Expr1033239 | |||||||||
| Expr1144428 | |||||||||
| Expr2000712 | |||||||||
| Expr2018934 | |||||||||
| Drives_construct | WBCnstr00003306 | ||||||||
| WBCnstr00011903 | |||||||||
| WBCnstr00019385 | |||||||||
| WBCnstr00033674 | |||||||||
| Construct_product | WBCnstr00019385 | ||||||||
| WBCnstr00033674 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (92) | |||||||||
| Interaction | WBInteraction000007874 | ||||||||
| WBInteraction000351061 | |||||||||
| WBInteraction000391089 | |||||||||
| WBInteraction000440972 | |||||||||
| WBInteraction000449498 | |||||||||
| WBInteraction000458315 | |||||||||
| WBInteraction000521813 | |||||||||
| WBInteraction000555271 | |||||||||
| Map_info | Map | X | Position | 16.6789 | |||||
| Positive | Positive_clone | C11H1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027315 | ||||||||
| WBPaper00028592 | |||||||||
| WBPaper00029085 | |||||||||
| WBPaper00031872 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
